What's New in Rare CKDs?.

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Presentation transcript:

What's New in Rare CKDs?

Challenge With Rare CKDs

Exome Sequencing in Kidney Disease

Clinical Implications of Exome Sequencing

Pathway for Renal Disease Progression

New Treatment Target in CKD

Bardoxolone Mechanism of Action

Chronic Inflammation Plays a Central Role in CKD Progression

Bardoxolone in ADPKD

Treatment of ADPKD: Combining Complementary Mechanisms

Problems Faced When Dealing With PKD

Multiple Drug Approach to Treatment of CKD

Exclusion of At-Risk Patients in BEACON Appears to Improve Risk-Benefit Profile of Bardoxolone

PHOENIX Study Bardoxolone in Patients With Rare CKDs

PHOENIX: FSGS Population

Increases in Urinary Protein Are Consistent With Increases in GFR and Not Injury

CARDINAL Study Phase 2 Study in Patients With Alport Syndrome

Abbreviations

Abbreviations (cont)

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