JMJD2B and CDK6 expressions are significantly correlated in various types of cell lines. JMJD2B and CDK6 expressions are significantly correlated in various.

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JMJD2B and CDK6 expressions are significantly correlated in various types of cell lines. JMJD2B and CDK6 expressions are significantly correlated in various types of cell lines. A, quantitative real-time PCR analysis of one normal cell line (HFL1), 5 lung cancer cell lines (A549, RERF-LC-AI, ACC-LC-319, H2170, and SBC5), 2 bladder cell lines (253J and SCaBER), 3 colorectal cancer cell lines (SW480, HCT116, and LoVo), 2 liver cancer cell lines (HepG2 and Huh-7), and 1 cervical cancer cell line. Expression levels of p16INK4a, JMJD2B and CDK6 were examined. mRNA expression levels were normalized to GAPDH, and values are relative to HFL1. B, correlation among p16INK4a, JMJD2B, and CDK6 expressions in 14 cell lines analyzed by quantitative real-time PCR. Pearson r correlation was used to measure the relationship between the expression of the 2 genes. C, correlation between JMJD2B and CDK6 expressions in 7 cell lines expressing low levels of p16INK4a (HFL1, A549, ACC-LC-319, H2170, 253J, LoVo, and HepG2) analyzed by quantitative real-time PCR. Pearson r correlation was used to measure the expression of relationship between the expression of the 2 genes. Gouji Toyokawa et al. Cancer Prev Res 2011;4:2051-2061 ©2011 by American Association for Cancer Research