Carbon monoxide (CO) delivery system used in animal models and Phase 1 clinical trials. Carbon monoxide (CO) delivery system used in animal models and.

Slides:



Advertisements
Similar presentations
The patient is being ventilated with 2 types of breaths.
Advertisements

The changes in peak flow and inspiratory time between a minimum rise time (first 2 breaths) and a maximum rise time (last 2 breaths), with the Servo-i.
Airway pressure and flow waveforms during constant flow volume control ventilation, illustrating the effect of an end-inspiratory breath-hold. Airway pressure.
Air flow during ventilator-supported speech production.
Lung CT images were obtained while tracing the curve in static conditions. Lung CT images were obtained while tracing the curve in static conditions. Note.
Schematic illustration of upper airway anatomical dead space volume (VD) during unidirectional breathing. Schematic illustration of upper airway anatomical.
Lung simulator diagram of airway pressure release ventilation (APRV): volume (yellow), lung pressure (white), and flow (orange)/time curve. Lung simulator.
Trigger delays and leaks.
The 3-compartment lung model described by Riley and Cournand151,152 represents gas exchange in the lung in regard to the matching of alveolar gas volume.
HomeLOX liquid oxygen system, which creates oxygen from a concentrator and refrigerates the concentrator gas to a liquid state, which is stored in a small.
The Spectrum mask incorporates the leak port into the circuit, whereas the Mirage mask incorporates the leak port into the mask. The Spectrum mask incorporates.
Shape-signal method of triggering combines shape signal (A) and volume (B) methods of triggering. Shape-signal method of triggering combines shape signal.
A ventilator and TTL test lung were used to simulate spontaneous breathing. A ventilator and TTL test lung were used to simulate spontaneous breathing.
Several potential sources of error in esophageal manometry are illustrated in this transverse section of the thorax. Several potential sources of error.
The high flow nasal cannula (HFNC) system incorporated an air/O2 blender with a flow meter and a heated humidifier. The high flow nasal cannula (HFNC)
Noninvasive ventilation-neurally adjusted ventilatory assist (NIV-NAVA) where each patient effort is captured but support is insufficient (maximum electrical.
An example of delayed cycling during pressure-support ventilation of a patient with COPD, on a Puritan Bennett 7200 ventilator, which has a flow-termination.
Simulated screenshot of flow starvation in volume control continuous mandatory ventilation. Simulated screenshot of flow starvation in volume control continuous.
Characteristics of a pressure-supported breath.
A: Schematic representation of the heterogeneity of the lungs of patients with ARDS. Normal alveoli are subject to injury due to overdistention, whereas.
The peak flows (60 L/min) and flow patterns are the same for all the breaths. The peak flows (60 L/min) and flow patterns are the same for all the breaths.
Diffusing capacity of the lung for carbon monoxide (DLCO) (squares) decreases with incomplete inhalations of the test gas. Diffusing capacity of the lung.
Representative tracings of transcutaneous CO2 (PtcCO2), Spo2, and heart rate during an apnea test designed to raise Paco2 to 100 mm Hg. At baseline, PtcCO2.
A: Machine-triggered intermittent mandatory ventilation (IMV) with inadequate patient triggering of mandatory breaths. A: Machine-triggered intermittent.
Trigger and synchronization windows.
Illustrated here are several features used to determine that the esophageal balloon is correctly placed in the esophagus. Illustrated here are several.
Top: Stress index (SI) in a patient early in the course of ARDS
In this tracing of 30 seconds, 4 breaths are ineffectively triggered (arrows IT) and 7 are effectively triggered. In this tracing of 30 seconds, 4 breaths.
Graphic representation of a dynamic airway pressure scalar during volume control ventilation with a constant inspiratory flow. Graphic representation of.
Schematic drawing of alveolar sizes at upper (A), middle (B), and lower dependent (C) lung regions at end expiration and end inspiration. Schematic drawing.
Effect of respiratory mechanics on cycling of pressure support from inhalation to exhalation. Effect of respiratory mechanics on cycling of pressure support.
The use of a real time analyzer during a single brief inhalation-exhalation of methane (CH4), acetylene (C2H2), and carbon monoxide (CO). The use of a.
Flow, esophageal pressure, airway pressure, and transpulmonary pressure can be used to calculate respiratory system compliance, chest-wall compliance,
We connected the supplemental oxygen supply at 3 places: near the ventilator, near the exhalation valve, and on the nasal mask port. We connected the supplemental.
Blom speech cannula. Blom speech cannula. Inspiratory pressure opens the flap valve and closes (expands) the bubble valve, sealing the fenestration so.
Schematic representation of the proposed definition of prolonged mechanical ventilation (PMV) in neonates and children. Schematic representation of the.
Control circuit for set-point or dual targeting schemes.
A: Scanning electron microscopy image of Bivona TTS silicone tube after 3 months of use. A: Scanning electron microscopy image of Bivona TTS silicone tube.
Assembly used to convert a standard ventilator to an intermittent mandatory ventilation circuit. Assembly used to convert a standard ventilator to an intermittent.
Screen shot of test acceptability and reproducibility for spirometry (upper panel) and diffusion capacity of the lung for carbon monoxide (DLCO) (lower.
A: Changes in percent of predicted following bronchodilator for spirometric and lung volumes variables. A: Changes in percent of predicted following bronchodilator.
Control circuit for a servo targeting scheme (eg, Proportional Assist Ventilation). Control circuit for a servo targeting scheme (eg, Proportional Assist.
A: Evolution of clinically observed signs after 38 patients received high-flow nasal cannula oxygen. A: Evolution of clinically observed signs after 38.
Total drug dose by device and condition while delivering 1 mL of ribavirin (5 min for the small-particle aerosol generator [SPAG] or 2 min for the vibrating.
The cause of asynchrony during volume-targeted ventilation and total asynchrony index. The cause of asynchrony during volume-targeted ventilation and total.
Mean inspiratory work of breathing during assisted breaths and spontaneous breaths across the spectrum of ventilatory support continuous mandatory ventilation.
Flow, airway pressure, and transversus abdominis electromyogram (EMG) waveforms from a mechanically ventilated patient with COPD receiving pressure-support.
Schematic of mechanisms behind the better recruitment of alveoli with spontaneous breathing. Schematic of mechanisms behind the better recruitment of alveoli.
Components of a patient-triggered mechanical breath.
FEV1 and FVC for the control group (without noninvasive ventilation [NIV]), NIV with an inspiratory pressure (IPAP) of 15 cm H2O and expiratory pressure.
Determinants of patient-ventilator interaction.
Correlation between maximum inspiratory pressure and inspiratory load compensation (ILC) ventilatory variables in the 16 difficult-to-wean subjects, prior.
Airway pressure and flow graphics illustrate delayed cycling.
Ventilation protocol. Ventilation protocol. The PEEP group raised peak inspiratory pressure (PIP) through 5-cm H2O PEEP increments every 2 min while keeping.
The changes in peak flow and inspiratory time between a minimum rise time (first 2 breaths) and a maximum rise time (last 2 breaths), with the Servo-i.
Relationship between airway resistance (Raw) and lung volume, the reciprocal of Raw (conductance of the airways [Gaw]) and lung volume, and Gaw/TGV (thoracic.
Experimental setup. Experimental setup. Each tested ventilator was connected to the TTL test lung via a ventilator circuit. An oxygen analyzer, a pressure.
Progression of spontaneous breathing trials administered during inspiratory muscle strength training study interventions. Progression of spontaneous breathing.
Delivery efficiency with different devices, ventilator positions, and ventilator settings. Delivery efficiency with different devices, ventilator positions,
Efficiency of aerosol bronchodilator delivery during continuous high-flow system at different CPAP and flow levels. Efficiency of aerosol bronchodilator.
Lung model expiratory CO2 (or PETOv2) representing simulated alveolar CO2 at baseline (no high-flow nasal cannula) and effect on expiratory CO2 at different.
A: Comparison of pediatric lung transplant survival between different age groups. A: Comparison of pediatric lung transplant survival between different.
Average drug doses in the peripheral lung, central lung, and extrathoracic airway; residual drug left in the device; and residual drug that was exhaled.
Basic setup for high-flow nasal cannula oxygen delivery.
Percent of extremely-low-birth-weight (ELBW) babies alive and off mechanical ventilation at 7 days, and median days on mechanical ventilation for ELBW.
The 3 compartment lung model described by Riley36,37 represents gas exchange in the lung in regards to the matching of alveolar ventilation (V̇A) and perfusion.
Fentenyl and lorazepam use for the first 5 d of ventilatory support are presented. Fentenyl and lorazepam use for the first 5 d of ventilatory support.
Mean ± SD PEEP requirements from randomized clinical trials of lung-protective ventilation whereby PEEP and FIO2 were titrated to maintain PaO2
Minute-by-minute means of breathing variables during the spontaneous breathing trial for the groups of subjects with trial success (n = 32) and failure.
Setup of the BiPAP Synchrony with an inspiratory filter and single-limb passive circuit, with the filter placed over the fixed leak to collect aerosol.
Presentation transcript:

Carbon monoxide (CO) delivery system used in animal models and Phase 1 clinical trials. Carbon monoxide (CO) delivery system used in animal models and Phase 1 clinical trials. A: Front view. B: Schematic including ventilator, CO delivery system with injector module, and CO gas cylinder. C: Volumetric mixing data using the CO delivery system, a mechanical ventilator, and test lung. Flow-matching results in instantaneous flow of CO gas proportional to the inspiratory flow (Vent Flow) to deliver and maintain a precise and constant CO concentration. From Reference 95, with permission. Dean R Hess Respir Care 2017;62:1333-1342 (c) 2012 by Daedalus Enterprises, Inc.