Overexpression of JMJD2B in clinical bladder cancers.

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Overexpression of JMJD2B in clinical bladder cancers. Overexpression of JMJD2B in clinical bladder cancers. A, mRNA levels of JMJD2B in representative cases of clinical normal bladder tissues and bladder cancer tissues (British). B, quantitative real-time PCR measurements were carried out using 76 bladder cancer samples and 20 normal bladder samples, and the result is shown by box-whisker plot. For statistical analysis, the Mann–Whitney U test was adopted (mean: 41.47 (tumor) versus 7.86 (normal), P < 0.0001). C, immunohistochemical analysis of JMJD2B in bladder tissues. Clinical information for each section is represented above histologic pictures. All tissue samples were purchased from BioChain. Original magnification: ×200. Gouji Toyokawa et al. Cancer Prev Res 2011;4:2051-2061 ©2011 by American Association for Cancer Research