Β-Cryptoxanthin at a concentration of 10 μmol/L decreases proliferation in HCT116 cells after 6 and 8 days of treatment. β-Cryptoxanthin at a concentration.

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β-Cryptoxanthin at a concentration of 10 μmol/L decreases proliferation in HCT116 cells after 6 and 8 days of treatment. β-Cryptoxanthin at a concentration of 10 μmol/L decreases proliferation in HCT116 cells after 6 and 8 days of treatment. A, cell proliferation measured by MTT assay; B, cell density measured with a cell-counter apparatus; C, quantification of BrdUrd incorporation (left) and representative plots (right); D, doubling time calculation; E, quantitative real-time PCR analysis of ΔNP73 mRNA levels after treatment; F, apoptosis assay by flow cytometry analysis using Annexin V-FITC/IP staining. *, P < 0.05; **, P < 0.01. Mean ± standard deviation of at least three independent experiments is represented. Coral San Millán et al. Clin Cancer Res 2015;21:4398-4409 ©2015 by American Association for Cancer Research