The Hippo pathway acts as a modifier of pNF.

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The Hippo pathway acts as a modifier of pNF. The Hippo pathway acts as a modifier of pNF. A and D, Picture of the cervical and trunk spinal cord and peripheral nerves (A) and sciatic nerves (D) of H7;Nf1mut (left plots), H7;Lats1/2mut (middle plots), and H7;Nf1mut;Lats1/2mut (right plots). B and E, Histologic evaluation of DRGs (B) and sciatic nerves (E) as a function of the genotype. C and F, Scatter plot of (C) the number of enlarged DRGs (>1 mm diameter) and (F) diameter of sciatic nerves as a function of genotype. G, Kaplan–Maier plot illustrating the percentage of mice surviving as a function of time and genotype. **, P < 0.01; ***, P < 0.001. Scale bars, 50 μm. Zhiguo Chen et al. Cancer Discov 2019;9:114-129 ©2019 by American Association for Cancer Research