Small intestine without mucosa as a growing vascular conduit: A porcine experimental study Om P. Tucker, MD, Thomas Syburra, Monique Augstburger, RN,

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Presentation transcript:

Small intestine without mucosa as a growing vascular conduit: A porcine experimental study Om P. Tucker, MD, Thomas Syburra, Monique Augstburger, RN, Guy van Melle, PhD, Sandra Gebhard, MD, Fred Bosman, MD, Ludwig K. von Segesser, MD The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 6, Pages 1165-1175 (December 2002) DOI: 10.1067/mtc.2002.125818 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Plicated SIWM graft at implantation. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 A, Photograph showing septae (S) near superior anastomosis of opened up graft and IVC. B, Photomicrograph of graft (GR) with attached septa (S) showing similar histologic appearance. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Photomicrograph of graft under low power before implantation showing different layers. sm, Submucosa; lsm, longitudinal smooth muscle; csm, circular smooth muscle; ss, subserosa; s, serosa. (Magnification 20×.) The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Photomicrograph of graft under high power before implantation showing different layers. sm, submucosa; MM, muscularis mucosae; sc, stratum compactum. (Magnification 100×.) The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Nearly normal appearing SIWM graft with plicating sutures and IVC at explantation. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Opened up SIWM graft at explantation showing smooth, glistening endothelial surface and wide anastomoses. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 7 Photomicrograph of van Gieson-elastin stain of graft at anastomotic site showing presence of elastic fibers (black spots with arrow) in tunica media (TM) of IVC and absence of same on graft side. ta, Tunica adventitia; gr, graft; ti, tunica intima. (Magnification 40×.) The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 8 Photomicrograph showing endothelial cells (ec) staining positively for factor VIII-related antigen in lining of graft. (Magnification 200×). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 9 Photomicrograph of explanted graft showing proliferating fibroblasts (mf) staining positively for MIB1 antigen. (Magnification 400×). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 10 Graph showing weights of animals in kilograms (circles) and lengths of grafts in millimeters (triangles) at implantation (1) and explanation (2). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1165-1175DOI: (10.1067/mtc.2002.125818) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions