Analysis of thermal stability and aggregation properties before and after disulfide stabilization of the pMHCI complex. Analysis of thermal stability and.

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Analysis of thermal stability and aggregation properties before and after disulfide stabilization of the pMHCI complex. Analysis of thermal stability and aggregation properties before and after disulfide stabilization of the pMHCI complex. A, dynamic light scattering analysis of thermal stability of single pMHCI-bivalent IgG before (purple) and after (blue) disulfide stabilization. Reference IgG antibody (Herceptin) without pMHCI fusion (green) was included as control. B and C, analytic SEC of single pMHCI-bivalent IgG after protein A chromatography purification before (B) and after disulfide stabilization (C). Martina Schmittnaegel et al. Mol Cancer Ther 2016;15:2130-2142 ©2016 by American Association for Cancer Research