Innervation patterns and synaptic efficacy between VD4 and LPeD1 cells is temporally regulated. Innervation patterns and synaptic efficacy between VD4.

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Presentation transcript:

Innervation patterns and synaptic efficacy between VD4 and LPeD1 cells is temporally regulated. Innervation patterns and synaptic efficacy between VD4 and LPeD1 cells is temporally regulated. To define the precise pattern of synaptic innervation between VD4 and multiple LPeD1 cells, these neurons were juxtaposed against VD4 at different time points. Top (box), experimental paradigm. VD4 was paired with LPeD1a, and the second LPeD1 (LPeD1b) was brought into contact either simultaneously or 1 or 4 hr after contact with the first cell. Pairwise intracellular recordings were made 4 hr after LPeD1b was juxtaposed. When juxtaposed simultaneously, both LPeD1 cells (a and b) were innervated by VD4. Induced action potentials in VD4 generated 1:1 EPSPs in both cells (Ai, Aii). However, when LPeD1b was juxtaposed with VD4 4 hr after LPeD1a, a synapse was detected only in LPeD1a (Aiii, Aiv). B, C, Summarized data of the percentage of synapses formed (B) and absolute EPSP amplitude with each target (C). D, E, Average EPSP amplitude recorded in each postsynaptic target in triplet configuration paired simultaneously (D) or after a 4 hr delay (E). D, EPSP data are shown only for those triplets in which a synapse was formed with both targets. David W. Munno et al. J. Neurosci. 2003;23:4146-4155 ©2003 by Society for Neuroscience