Effect of sulindac and atorvastatin on the cell cycle.

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Effect of sulindac and atorvastatin on the cell cycle. Effect of sulindac and atorvastatin on the cell cycle. (A) Heat map of cell cycle regulatory genes that are differentially expressed in untreated tumour-bearing mice versus those treated with Sul/Atorva. Neoplastic colonic epithelial cells were laser microdissected for microarray analyses. The intensity of the colour indicates the degree of upregulation (magenta) or downregulation (green) when the data are expressed as a ratio (Sul/Atorva vs control). Multiple listings of a gene reflect the analysis of several probes for the same gene. (B) Sul/Atorva induces cell cycle arrest. SW480 human colon carcinoma cells were treated with various doses of sulindac, atorvastatin or Sul/Atorva for 48 hours, stained with propidium iodide and analysed by flow cytometry for DNA content. Histograms were generated using FlowJo software. Values from a representative experiment are presented, with similar results obtained in two independent experiments. Atorva, atorvastatin; DMSO, dimethyl sulfoxide; Sul, sulindac. Wen-Chi L Chang et al. Gut 2018;67:1290-1298 Copyright © BMJ Publishing Group Ltd & British Society of Gastroenterology. All rights reserved.