Rate of current rundown through VDCC and NMDA receptor channels is reduced in gelsolin-deficient hippocampal neurons. Rate of current rundown through VDCC.

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Presentation transcript:

Rate of current rundown through VDCC and NMDA receptor channels is reduced in gelsolin-deficient hippocampal neurons. Rate of current rundown through VDCC and NMDA receptor channels is reduced in gelsolin-deficient hippocampal neurons. A, Whole-cell Ca2+ current was recorded in G+/+ and G−/− hippocampal neurons at 10 sec intervals. Top, Representative current recordings taken from a G+/+ neuron and a G−/− neuron at the onset of the experiment and 400 sec later. Bottom, Data from recordings of whole-cell Ca2+ currents in G+/+, G+/−, and G−/− neurons. Values are the ± SEM of determinations made in six to eight neurons. The difference in rate of current rundown was significantly less in the G−/− neurons compared with the G+/+ neurons (p < 0.001 by ANOVA). B, NMDA-induced current was recorded in G+/+ and G−/− hippocampal neurons at 2 min intervals. Top, Representative current recordings taken from a G+/+ neuron and a G−/− neuron at the onset of the experiment and 30 min later. Bottom, Data from recordings of whole-cell NMDA-induced currents in G+/+, G+/−, and G−/− neurons. Values are the mean ± SEM of determinations made in six to nine neurons. The difference in rate of current rundown was significantly less in the G−/− neurons compared with the G+/+ neurons (p < 0.001 by ANOVA). C, Kainate-induced currents were recorded in G+/+ and G−/− hippocampal neurons at 2 min intervals. Top, Representative current recordings taken from a G+/+ neuron and a G−/− neuron at the onset of the experiment and 30 min later. Bottom, Data from recordings of whole-cell kainate-induced currents in G+/+, G+/−, and G−/− neurons. Values are the mean ± SEM of determinations made in six to nine neurons. Katsutoshi Furukawa et al. J. Neurosci. 1997;17:8178-8186 ©1997 by Society for Neuroscience