Androgenetic alopecia Done by : Rina Karborani

Cause? familial linked to high levels of dihyrotestosterone (DHT) levels Increased levels of androgens in hair follicles can lead to a shorter cycle of hair growth and the growth of shorter and thinner strands of hair. Additionally, there is a delay in the growth of new hair to replace strands that are shed. In female-pattern hair loss, there may be an increased sensitivity to circulating androgen, as androgen levels are usually within normal limits.

Patient presentation and clinical course Temples then crown ( can be quickly or slowly) following a family pattern Diffuse hair loss , particularly over crown area ( slow progression)

complications great anxiety that rarely progress to a monosymptomatic hypochondriasis ( even in minor hair loss) Sun burn to the scalp and may develop to multiple actinic keratoses. Some studies suggested that bald men are more likely to have a heart attack and prostate cancer than those with a full head of hair.

investigations hormonal testing is usually not needed unless symptoms or signs of androgen excess are present such as hirsutism, severe unresponsive acne or virilization.

Treatment Scalp surgery, hair transplants and wigs Topical application of minoxidil lotion or foam ( antihypertensive formula) may slow early hair loss and even stimulate new growth of hair Some females benefit from using oral antiandrogens ( spironolactone) Finasteride ; human type II 5α-reductase inhibitor { reduces serum and skin DHT levels } not indicated for women and children Side effects are rare, but include decreased libido, erectile dysfunction and altered prostate-specific antigen levels.

References: 1) book 2) https://ghr.nlm.nih.gov/ Thank you References: 1) book 2) https://ghr.nlm.nih.gov/