Volume 6, Issue 1, Pages 5-11 (July 2002)

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Volume 6, Issue 1, Pages 5-11 (July 2002) Baculovirus as Mammalian Cell Expression Vector for Gene Therapy: An Emerging Strategy Sudip Ghosh, Md.Khalid Parvez, Kakoli Banerjee, Shiv K. Sarin, Seyed E. Hasnain Molecular Therapy Volume 6, Issue 1, Pages 5-11 (July 2002) DOI: 10.1006/mthe.2000.0643 Copyright © 2002 American Society for Gene Therapy Terms and Conditions

FIG. 1 Life cycle of baculoviruses. Upon ingestion, the OBs or polyhedra are lysed inside the gut of the larvae to release PDVs. Once the PDVs enter the nucleus through primary infection, the viral DNA is uncoated and undergoes replication and transcription, giving rise to BVs that in turn cause secondary infection. Also, the progeny viruses get embedded into OBs which are released upon death of the host. Molecular Therapy 2002 6, 5-11DOI: (10.1006/mthe.2000.0643) Copyright © 2002 American Society for Gene Therapy Terms and Conditions