H19 was essential for cancer metastasis.

Slides:

Advertisements

Similar presentations

Diminished suppressive potency of primary Treg clones from IPEXA384T patients. Diminished suppressive potency of primary Treg clones from IPEXA384T patients.

Advertisements

Fibroblast activation in WT and NFATc2-deficient mice.

FIP200 loss links to poor autophagy and high apoptosis in naïve T cells in tumor. FIP200 loss links to poor autophagy and high apoptosis in naïve T cells.

Cytotoxicity of MSP samples to normal and cancer cell lines.

Degradation of MSP samples in 37°C DPBS solution.

CD8α+ DC-deficient mice are highly susceptible to Lm infection in the absence of CD169+ macrophages. CD8α+ DC-deficient mice are highly susceptible to.

Antitumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Antitumor effect of local cancer immunotherapy treatment toward.

Fluorescence-based in vivo imaging of MSP.

Three different types of transfer functions with a codomain of [0,1].

TPAD training protocol.

Workspace comparison of Delta robots.

T2-weighted cross-sectional MR imaging of MSP swarms inside SD rats.

FIP200 loss links to poor autophagy and high apoptosis in naïve T cells in tumor. FIP200 loss links to poor autophagy and high apoptosis in naïve T cells.

Human cells produce type I and III IFNs upon Af stimulation.

Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells. Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells.

Definition of the cellular source of IL-22.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

Tactile features for prosthesis perception.

BAP1 deficiency results in thymic atrophy and loss of thymocyte populations. BAP1 deficiency results in thymic atrophy and loss of thymocyte populations.

Neutrophil depletion ameliorates colitis in Cx3cr1cre:Il10rafl/fl BM chimeras. Neutrophil depletion ameliorates colitis in Cx3cr1cre:Il10rafl/fl BM chimeras.

Antitumor effect of local cancer immunotherapy treatment in various tumor models. Antitumor effect of local cancer immunotherapy treatment in various tumor.

Fig. 1 ZIKV RNA in blood and tissues.

CXCR5+/+ TFH cells are essential for the generation of LCMV-neutralizing antibodies and clearance of a persistent LCMV infection. CXCR5+/+ TFH cells are.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. (A)

T2-weighted cross-sectional MR imaging of MSP swarms inside SD rats.

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

Microrobots with different cell-carrying capacities under different grid lengths (lg) and burr lengths (lb). Microrobots with different cell-carrying capacities.

Genetic EGFR ablation in K-RAS–mutated lung AC reduces tumor growth

Degradation of MSP samples in 37°C DPBS solution.

Vaccine MN confer protective innate and adaptive immunity.

Fig. 3 NK cells are enriched in ICB-sensitive tumors in mouse models and patients and are required for response. NK cells are enriched in ICB-sensitive.

MYC degradation screen identifies a compound that stabilizes MYC protein. MYC degradation screen identifies a compound that stabilizes MYC protein. (A)

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. BMMs.

Fig. 1. Potent and selective down-regulation of KRAS mRNA and protein by AZD4785 in vitro and in vivo. Potent and selective down-regulation of KRAS mRNA.

STARmap for 3D transcriptome imaging and molecular cell typing.

by Emilie Clement, Hiroyuki Inuzuka, Naoe T

Galloping-like gait with the design of a two-legged robot.

AEGIS autonomous targeting process.

Fig. 1 IDH3α expression is elevated in human-derived gliomas.

Fig. 2 Extended local release of agonists of innate immunity prevents tumor recurrence and eliminates distal metastases. Extended local release of agonists.

Fig. 2 In vivo tumorigenicity of 4T1, CTC1, and DTC1 cells and EMT traits of DTC1-derived CTC lines. In vivo tumorigenicity of 4T1, CTC1, and DTC1 cells.

Fig. 4. Paclitaxel promotes the expression of invasive isoforms of MENA in the primary breast cancer microenvironment. Paclitaxel promotes the expression.

PD and efficacy of AZD4785 in KRAS mutant lung cancer xenograft models

Fig. 2 NDR2-deficient mice are more vulnerable to RNA viral infection.

Separation-of-function mutations in ATM dictate responses to DNA damage and oxidative stress. Separation-of-function mutations in ATM dictate responses.

Fig. 5 Cells cultured in Plasmax approximate the in vivo tumor metabolome better. Cells cultured in Plasmax approximate the in vivo tumor metabolome better.

Rif/mDia2 signaling in primary tumor formation and spontaneous metastasis. Rif/mDia2 signaling in primary tumor formation and spontaneous metastasis. A,

GM-CSF is required for CA-MSC–induced tumor metastasis.

Fig. 5 In vivo gene delivery by the T4-AAV nanoparticles.

Fig. 6 Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9 in vivo. Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9.

CD44 depletion blocks tumor cell aggregation and lung metastasis in vivo. CD44 depletion blocks tumor cell aggregation and lung metastasis in vivo. A,

SPARC is required for spontaneous metastasis

Fig. 8. TIE2 inhibitor rebastinib eliminates the prometastatic effects of paclitaxel. TIE2 inhibitor rebastinib eliminates the prometastatic effects of.

miR-146a is highly expressed selectively on γδ27− T cells.

The biomimetic pressure sensing ability.

Fibroblast activation in WT and NFATc2-deficient mice.

BV6 increases bone metastasis.

Fig. 1 RNA methyltransferase METTL14 and demethylase ALKBH5 promote growth and invasion of breast cancer cells. RNA methyltransferase METTL14 and demethylase.

Fig. 3. Paclitaxel promotes TMEM-dependent vascular permeability, cancer cell dissemination, and metastasis in breast cancer. Paclitaxel promotes TMEM-dependent.

Fig. 3 Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. Superiority of BAFF-R versus.

Fig. 3 Minimal treatment of ETL decreases metastatic burden and prolongs survival in the 4T1 breast carcinoma model after tumor resection. Minimal treatment.

Meningeal γδ T cell homeostasis is independent of inflammatory signals

Fig. 1 Cellular PFAS negatively regulates RTA-dependent transcriptional activation. Cellular PFAS negatively regulates RTA-dependent transcriptional activation.

PD and efficacy of AZD4785 in a KRAS wild-type lung cancer PDX model

Fig. 2 IDH3α regulates GBM progression in vivo.

Fig. 5. Paclitaxel promotes breast cancer cell dissemination and metastasis in a MENA-dependent manner. Paclitaxel promotes breast cancer cell dissemination.

CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis. CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis.

Fig. 5 CD19-tPSMA(N9del) CAR T cell numbers in mouse and human.

Presentation transcript:

H19 was essential for cancer metastasis. H19 was essential for cancer metastasis. (A) The classification for pair comparison between cell clones with differently metastatic potency (group N, nonmetastatic clones; group W, weakly metastatic clones; group H, highly metastatic clones). (B) qRT-PCR analysis of H19 abundance in 16 heterogeneous subclones isolated from the primary tumor of one TA2 mice with spontaneous breast cancer and normalized to that in clone 1. (C) qRT-PCR assessment of H19 abundance in metastatic 168FARN, 4TO7, and 4T1 cells and nonmetastatic 67NR cells and normalized to that in mouse mammary epithelial Scp2 cells. (D) qRT-PCR assessment of H19 abundance in TA2-C13 and TA2-C47 cells infected with lentiviral short hairpin RNA (shRNA) control or H19 shRNA and normalized to U6 small nuclear RNA (snRNA). (E) IVIS bioluminescence imaging of mice (n = 3 each) or extracted tissue from syngeneic TA1 mice 4 weeks after orthotopic injection of TA2-C13 and TA2-C47 cells transfected with luciferase and H19 shRNA or control shRNA. (F) The circulating tumor cells (CTCs) and metastatic lesions were calculated from syngeneic TA1 mice 4 weeks after orthotopic injection of TA2-C13 and TA2-C47 cells transfected with luciferase and H19 shRNA or control shRNA. (G) qRT-PCR assessment of H19 abundance of primary tumors from 48 primary breast cancer (PBC) patients and of metastases from 60 metastatic breast cancer (MBC) patients and normalized to U6 snRNA (Sh-Ctr, shRNA control; Sh-H19, H19 shRNA). Data are means ± SD from three independent experiments. **P < 0.01, ***P < 0.001. Wu Zhou et al., Sci. Signal. 2017;10:eaak9557 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.