Inhibitory effect of different doses of IP6 on prostate tumor progression in TRAMP mice. Inhibitory effect of different doses of IP6 on prostate tumor.

Slides:

Advertisements

Similar presentations

A, Effect of folate-FITC (500 nmol/kg, 5 days/week) and/or sunitinib (20 mg/kg daily) therapy on the growth of M109 tumors in Balb/c mice. A, Effect of.

Advertisements

IHC analyses of levels and/or phosphorylation status of selected proteins from representative sections of ventral prostate of Hi-Myc mice. IHC analyses.

Nonclassical monocytes are specifically depleted following M-CSFR inhibition and these cells are highest in PD-L1 expression in blood of mice during therapy.

Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.

Number of 0.5-Mb windows with chromosome lesions that reached statistical significance across patients in early (BE early and BE instability) and late.

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

Schematic representation of experimental design for BSp dietary treatments. Schematic representation of experimental design for BSp dietary treatments.

Mouse lymphoma model. Mouse lymphoma model. A, EL-Arf−/− cells (1 × 106) were tail-vein injected into C57BL/6 mice. LNIWC imaging was separated into 2.

IL-27 induces expression of multiple IR by CD8+ T cells.

Gross and histologic features of the intestinal neoplasms initiated by the Apc1638N mutation. Gross and histologic features of the intestinal neoplasms.

Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.

The presence of soluble IL12p70 during moDCpoly stimulation of KIRnegNKG2Aneg cells results in a dominant population of multifunctional NKG2Apos NK cells.

Diagnostic performance of dentist clinical impression.

Socially isolated SV40 Tag mice develop significantly larger mammary gland tumors. Socially isolated SV40 Tag mice develop significantly larger mammary.

Effects of DPM treatment on tumor volume, tumor mass, and pulmonary metastasis at experimental end point. Effects of DPM treatment on tumor volume, tumor.

Effects of maternal exposure during pregnancy to tap water (control), LIM, or HIM on offspring tumor incidence (% rats with tumors; A), tumor multiplicity.

A, effect of IP6 feeding on the weight of LUT organs normalized to body weight. A, effect of IP6 feeding on the weight of LUT organs normalized to body.

EPA+DHA supplementation does not alter body composition, body weight, or feed intake. EPA+DHA supplementation does not alter body composition, body weight,

Anti-Flk-1 treatment inhibits growth of s. c. 4T1 and B16 tumors. s. c

Rapamycin decreases PD-L1 expression in lung tumors in vivo.

Vandetanib decreases tumor incidence and accumulation of HIF-2α, expression of c-Myc and growth factor receptors in the lung of hypoxic mice. Vandetanib.

Dose-dependent effect of IP6 feeding on molecules associated with tumor sustenance and glucose transportation in dorsolateral prostate of TRAMP mice. Dose-dependent.

Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.

EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.

Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY –treated Eker (Tsc2+/−)

HCCs with overexpression of biliary/progenitor marker genes.

Differential methylation at 12 selected HPV16 CpGs in cervical cells from premalignant lesions with biopsy-confirmed diagnoses from our original study.

N-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. n-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. HEC-1-A.

AMs contribute to the progression of EGFR-mutant lung adenocarcinoma.

Dual blockade of PD-1 and CTLA-4 directly activates CD4+Foxp3− cells in the absence of CD8+ or CD4+Foxp3+ cells. Dual blockade of PD-1 and CTLA-4 directly.

Activation of membrane-associated Akt is associated with loss of apoptosis in TgAPT121;Pten+/− prostates. Activation of membrane-associated Akt is associated.

Prostate tumor progression in TgAPT121 mice is accelerated and diversified by Pten heterozygosity. Prostate tumor progression in TgAPT121 mice is accelerated.

Influenza vaccine enhances NK cell function through IFN-α.

Establishment of 12 PDX from BRAF inhibitor–progressed patients.

Activity of a chemically modified miR-21 inhibitor in human bladder cancer xenografts. Activity of a chemically modified miR-21 inhibitor in human bladder.

The percentage of positive among all women (A), women with CIN2, or more severe diagnosis (CIN2+; sensitivity; B), and grade 3 (CIN3) or more severe diagnosis.

HMQ1611 inhibited breast tumor growth in mice.

Mean cell number in small intestinal crypt (a), small intestinal villus (b), and midcolonic crypt (c) of BALB/c (♦) and DBA/2 (▪) mice after two injections.

Apoptotic cell index percentage (a and b) and mitotic cell index percentage (c and d) in small intestinal (a and c) and midcolonic (b and d) crypts of.

Location of the ER mutations and frequencies per cohort.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.

The effect of a DIO regimen ± EPA+DHA supplementation on tumor growth.

Effect of dietary feeding of silibinin on DU145 tumor xenograft growth in athymic male nude mice. Effect of dietary feeding of silibinin on DU145 tumor.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Tumor protection induced by therapeutic PLG vaccination in combination with blockade antibodies. Tumor protection induced by therapeutic PLG vaccination.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Progastrin staining in colon adenomas and adenocarcinomas.

Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.

The best response for target lesions per patient for patients with target lesions assessed at baseline and at least 1 follow-up. The best response for.

Comparative effect of anti-TIM3 against experimental tumors.

RhuαVEGF and rhuαVEGF/paclitaxel mediated growth inhibition in an androgen-independent prostate cancer xenograft model. rhuαVEGF and rhuαVEGF/paclitaxel.

Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy. Immune checkpoint molecule expression in primary and secondary.

Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology. Reduced expression of the tumor.

Validation of NAA's cancer specificity in lung cancer.

PDL192 and inhibit the growth of xenograft tumors.

Increased growth factor receptor expression in lungs and tumors of hypoxic mice. Increased growth factor receptor expression in lungs and tumors of hypoxic.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

GCS-100 selectively kills KRAS-addicted lung tumors.

Venn diagram showing the overlap of PD-L1 overexpression, MSI-NGS–high, and TML-high in all gastrointestinal tumors, with all three markers tested (N =

Heterozygous Pik3caH1047R oncogenic mutation causes invasive prostate cancer in mice that does not phenocopy Pten deletion. Heterozygous Pik3caH1047R oncogenic.

CPI-444 synergizes with anti–PD-L1 and anti–CTLA-4 treatment.

Chemopreventive effect of bexarotene and budesonide on mouse SCLC

In vivo effect of KIN-193 on PTEN-deficient tumors.

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

Dose-dependent effect of IP6 feeding on angiogenesis in prostate of TRAMP mice. Dose-dependent effect of IP6 feeding on angiogenesis in prostate of TRAMP.

Quantification of biomarker candidates in prediagnostic plasmas from mouse models of colorectal cancer. Quantification of biomarker candidates in prediagnostic.

Comparison of PD-L1 mAbs in IHC across multiple tumor types.

DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. DHA and dietary n-3 PUFAs inhibit endometrial cancer.

Parthenolide inhibits tumor promotion and increases p21 expression in vivo. Parthenolide inhibits tumor promotion and increases p21 expression in vivo.

Presentation transcript:

Inhibitory effect of different doses of IP6 on prostate tumor progression in TRAMP mice. Inhibitory effect of different doses of IP6 on prostate tumor progression in TRAMP mice. Effect of IP6 feeding on, A, incidence of low and high grade PIN; B, adenocarcinoma lesions in dorsolateral prostate of TRAMP mice; C, tumor grade of dorsolateral prostate in TRAMP mice. D, Percentage area of dorsolateral prostate of positive control and IP6-fed groups having histologically diagnosed PIN, WD, MD, and PD adenocarcinoma characteristics. Error bars indicate ± SEM. NS, not significant. Komal Raina et al. Cancer Prev Res 2013;6:40-50 ©2013 by American Association for Cancer Research