In vivo efficacy and specificity of OTL78 in orthotopic and subcutaneous tumor models using the AMI image system. In vivo efficacy and specificity of OTL78.

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In vivo efficacy and specificity of OTL78 in orthotopic and subcutaneous tumor models using the AMI image system. In vivo efficacy and specificity of OTL78 in orthotopic and subcutaneous tumor models using the AMI image system. Representative fluorescence images from the AMI image system showing mice bearing (A) 22Rv1 subcutaneous (n = 3 mice/group), (B) LNCaP subcutaneous (n = 3 mice/group), and (C) 22Rv1 orthotopic (n = 5 mice/group) tumors 2 hours after administering 10 nmol/L of OTL78. Tissue biodistribution analysis of the same mice with (D) 22Rv1, (E) LNCaP, and (F) 22Rv1 tumors at 2 hours after injection. Note: *Primary tumor is in the prostate in G; K, kidneys; PT, primary tumor; SC, secondary tumor; and SV, seminal vesicle. Sumith A. Kularatne et al. Clin Cancer Res 2019;25:177-187 ©2019 by American Association for Cancer Research