Valérie Bougault, PhD, Julie Turmel, MSc, Louis-Philippe Boulet, MD

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Presentation transcript:

Airway hyperresponsiveness in elite swimmers: Is it a transient phenomenon? Valérie Bougault, PhD, Julie Turmel, MSc, Louis-Philippe Boulet, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 4, Pages 892-898 (April 2011) DOI: 10.1016/j.jaci.2010.11.003 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Individual values for MCh in swimmers and controls at V1 and V2. Geometric mean is represented as a middle horizontal bar. Journal of Allergy and Clinical Immunology 2011 127, 892-898DOI: (10.1016/j.jaci.2010.11.003) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Individual values for EVH challenge in swimmers and controls at V1 and V2. Median is represented as a middle horizontal bar. Journal of Allergy and Clinical Immunology 2011 127, 892-898DOI: (10.1016/j.jaci.2010.11.003) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Positive/negative diagnosis for AHR to methacholine and/or EVH at V1 and V2 in swimmers. A positive diagnosis of AHR to MCh is defined by an MCh PC20 ≤4 mg/mL and/or by a fall in FEV1 post-EVH of ≥10% during a ≥5-minute period.10 Journal of Allergy and Clinical Immunology 2011 127, 892-898DOI: (10.1016/j.jaci.2010.11.003) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Relationship between changes from V1 to V2 of FeNO and MCh PC20 (A) and EVHf (B) in swimmers and controls. Change in log MCh PC20 (V2-V1), Change in log PC20 to methacholine from V1 to V2; EVHf (V2-V1), change in the maximum fall in FEV1 after the EVH test from V1 to V2; FeNO (V2-V1), change in exhaled nitric oxide from V1 to V2. A, The regression equation for swimmers is y = 8.6x + 3.0 (r = –.46; P = .04). B, The regression equation for controls is y = 1.4x – 2.2 (r = .67; P = .005). Journal of Allergy and Clinical Immunology 2011 127, 892-898DOI: (10.1016/j.jaci.2010.11.003) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions