Schematic representation of a rotavirus virion.

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Schematic representation of a rotavirus virion. Schematic representation of a rotavirus virion. The virus is composed of three protein shells, an outer capsid, an inner capsid, and an internal core, that surround the 11 segments of double-stranded RNA. The outer capsid proteins VP4 and VP7 are neutralization antigens and define the P and G serotypes, respectively. VP6, the inner capsid structural protein, is the subgroup antigen. (Reprinted from reference 1 by permission from Macmillan Publishers.)‏ Penelope H. Dennehy Clin. Microbiol. Rev. 2008; doi:10.1128/CMR.00029-07