Quercetin induces arrest in G1 phase of cell cycle in P39 xenografts.

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Presentation transcript:

Quercetin induces arrest in G1 phase of cell cycle in P39 xenografts. Quercetin induces arrest in G1 phase of cell cycle in P39 xenografts. NOD/SCID mice with P39 tumors were administered without or with quercetin (120 mg/kg), once every 4 days. A to G, after 3 weeks, tumors were harvested and relative levels of protein in the tumor lysates were determined by Western blotting. H, IHC analysis of p21 protein in tumor sections. I, the percentage of p21-positive nuclei of cells per field; four fields per tumor section. Counts were made using a ×40 objective connected to a light microscope (Olympus CBA, Olympus America) Values are means ± SD (mean of 6 mice/group); *, P < 0.05; **, P < 0.0001. Victor Maso et al. Cancer Prev Res 2014;7:1240-1250 ©2014 by American Association for Cancer Research