Quercetin induces apoptosis in P39 xenografts.

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Quercetin induces apoptosis in P39 xenografts. Quercetin induces apoptosis in P39 xenografts. NOD/SCID mice with P39 tumors were administered without or with quercetin (120 mg/kg) once every 4 days. A to D, after 3 weeks, tumors were harvested and relative levels of protein in the tumor lysates were determined by Western blotting. E, IHC analysis of cleaved caspase-3 in tumor sections. F, the percentage of cleaved caspase-3–positive nuclei of cells per field; four fields per tumor section. Counts were made using a ×40 objective connected to a light microscope (Olympus CBA; Olympus America). Values are means ± SD (mean of 6 mice/group); *, P < 0.05; **, P < 0.0001. Victor Maso et al. Cancer Prev Res 2014;7:1240-1250 ©2014 by American Association for Cancer Research