David J.A. Jenkins et al. JACC 2018;71:

Slides:

Advertisements

Similar presentations

Supplemental Figure 1 A No. at risk T T T

Advertisements

Edgar R. Miller III et al. Ann Intern Med. 2005; 142 Clinical Trials of Vitamin E Supplementation and Risk for All-Cause Mortality, Ordered by Dosage of.

How to Analyze Systematic Reviews: practical session Akbar Soltani.MD. Tehran University of Medical Sciences (TUMS) Shariati Hospital

The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. N Engl J Med 2006; available at: End pointActive therapy PlaceboRelative.

Flow Diagram of Identification of Randomized Trials for Inclusion Goran Bjelakovic, et al. JAMA. 2007;297:

The FAVORIT Study (Folic Acid for Vascular Outcome Reduction in Transplantation) Source Bostom AG, Carpenter MA, Kusek JW, et al. Homocysteine-lowering.

Date of download: 9/16/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cranberry-Containing Products for Prevention of Urinary.

Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Patients With Diabetes: A Meta-Analysis Stavros Stavrakis, MD The American Journal.

A) b) Supplementary Figure 1A: Significance plot(a) and forest plot(b) for the most significant SNP for regions of interest from the meta-analysis of IGP29.

Copyright © 2012 American Medical Association. All rights reserved.

Characteristics of the Folic Acid and Placebo Groups at the Start of the Study J. Durga et al. Arch Intern Med. 2005;165:

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids.

Systematic Review of Controlled Clinical Trials on the Use of Ursodeoxycholic Acid for the Prevention of Hepatic Veno-occlusive Disease in Hematopoietic.

Daniel J. Lenihan et al. BTS 2016;1:

Neonatal vitamin A: time to move on?

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids.

David J.A. Jenkins et al. JACC 2018;71:

Systematic reviews and meta-analysis

Fructose as a Driver of Diabetes: An Incomplete View of the Evidence

Dean J. Kereiakes et al. JACC 2017;70:

Relative risk of major events with atenolol vs placebo

Aspirin in the prevention of cancer – Author's reply

Ashish Shukla et al. JACEP 2015;1:41-51

David J. Tunnicliffe, Suetonia C. Palmer

P2Y12 blockade versus placebo; risk ratio with 95% CIs for the primary composite end point of cardiovascular death, non-fatal myocardial infarction and.

Dr. Maryam Tajvar Department of Health Management and Economics

Juan J. Russo et al. JACC 2019;73:

David J.A. Jenkins et al. JACC 2018;71:

David J.A. Jenkins et al. JACC 2018;71:

David J.A. Jenkins et al. JACC 2018;71:

The risk of cardiovascular events with increased apolipoprotein CIII: A systematic review and meta-analysis Moritz C. Wyler von Ballmoos, MD, MPH, Bernhard.

Forest plot displaying the effect estimates comparing azithromycin and placebo treatment in subgroups defined by above (>0.39 ng·mL−1) or below (

Yousef Rezaei, MD American Journal of Kidney Diseases

Hepatic Vein Pressure Gradient Reduction and Prevention of Variceal Bleeding in Cirrhosis: A Systematic Review Gennaro D’Amico, Juan Carlos Garcia-Pagan,

Subgroup analysis. Subgroup analysis. Effect of vitamin D supplementation on outcome variables in subgroups defined by baseline levels of the respective.

Ioannis Smyrnias et al. JACC 2019;73:

Toshiaki Toyota et al. JCIN 2017;10:27-37

Drug-eluting stents versus coronary artery bypass grafting for the treatment of coronary artery disease: A meta-analysis of randomized and nonrandomized.

Effect of Folic Acid, with or without Other B Vitamins, on Cognitive Decline: Meta- Analysis of Randomized Trials David S. Wald, MA, MRCP, MD, Anuradhani.

Relative Risk of Onset of Cancer from the Cholesterol Treatment Trialists’ (CTT) Meta-Analysis of Statin Trials, According to Year of Onset Risk ratios.

Lauren Brash et al. BTS 2018;3:

Forest plots for randomised and cluster randomised controlled trials from Cochrane review Biomarkers as point-of-care tests to guide prescription of antibiotics.

Neesh Pannu, Braden Manns, Helen Lee, Marcello Tonelli

Risk of having any adverse effects with supplements compared with placebo. Risk of having any adverse effects with supplements compared with placebo. Stratified.

David J.A. Jenkins et al. JACC 2018;71:

Keratinocyte growth factor (KGF) versus no KGF for the reduction of severe oral mucositis in patients receiving treatment for cancer or undergoing haematopoietic.

Nicholas J. Talley, Nimish B. Vakil, Paul Moayyedi Gastroenterology

Nicholas Z. Kerin, MD, Sony Jacob, MD The American Journal of Medicine

Contour-enhanced funnel plot of the 17 trials comparing haloperidol and placebo for clinical improvement in schizophrenia. Contour-enhanced funnel plot.

Volume 388, Issue 10042, Pages (July 2016)

Epigenome-wide differential methylation in RUL macrophages.

Volume 59, Issue 5, Pages (May 2001)

Zachary L. Steinberg et al. JACC 2017;69:

Zachary L. Steinberg et al. JACC 2017;69:

Forest plot of randomised controlled trials investigating the effects of pasta in the context of low-GI dietary patterns on body weight (kg). n=2448. Forest.

Plot of the pooled effect estimates from randomised controlled trials investigating the effects of pasta in the context of low-GI dietary patterns on global.

Pamela E. Scott et al. JACC 2018;71:

Pooled risk with 95% CI of ACM (A) and CVD risk (B) for the highest vs

Rebuttal From Drs Mohr and Doerschug

Treatment response patterns and effect size over time in exclusively placebo-controlled trials. Treatment response patterns and effect size over time in.

Forest plot and pooled estimates of the effect of NAFLD on the risk of incident diabetes in 16 eligible studies, stratified by length of follow-up (FU)

Cryotherapy versus no cryotherapy for the reduction of severe oral mucositis in patients receiving treatment for cancer or undergoing haematopoietic stem.

David J.A. Jenkins et al. JACC 2018;71:

Gianluigi Savarese et al. JCHF 2016;4:

David J.A. Jenkins et al. JACC 2018;71:

Pooled estimate of relative risk and 95% CIs of colorectal cancer associated with metformin therapy based on four studies comprising 107,961 diabetic patients.

Volume 3, Issue 1, Pages (January 2016)

Forest plot of platelet-rich plasma (PRP) versus control on tendinopathy pain. Forest plot of platelet-rich plasma (PRP) versus control on tendinopathy.

Forest plot for one-study removed sensitivity analysis of platelet-rich plasma (PRP) versus control on tendinopathy pain. Forest plot for one-study removed.

Catheter Type, Placement, and Insertion Techniques for Preventing Catheter-Related Infections in Maintenance Peritoneal Dialysis Patients: Summary of.

Presentation transcript:

David J.A. Jenkins et al. JACC 2018;71:2570-2584 Forest Plot of Vitamin B Complex Supplementation and Stroke Risk The diamond represents the pooled risk estimate. Interstudy heterogeneity was tested using the Cochran Q statistic (chi-square) at a significance level of p < 0.10 and quantified by the I2 statistic. This 10% stroke reduction comes from trials that also include folic acid and from areas with folic acid fortification. These results also support not only B-complex supplementation but also the positive effect of folic acid in stroke prevention. The NNT for vitamin B complex supplementation and stroke risk is 250. *Data for folic acid, B6, and B12 versus placebo from Bønaa et al. (36). †Data for folic acid, B6, and B12 versus placebo from Ebbing et al. (38). Abbreviations as in Figures 2 and 4. David J.A. Jenkins et al. JACC 2018;71:2570-2584 2018 The Authors