ZIKV-infected Ifnar1+/− fetuses show up-regulated hypoxia response genes just before demise. ZIKV-infected Ifnar1+/− fetuses show up-regulated hypoxia.

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ZIKV-infected Ifnar1+/− fetuses show up-regulated hypoxia response genes just before demise. ZIKV-infected Ifnar1+/− fetuses show up-regulated hypoxia response genes just before demise. Ifnar1−/− females mated to Ifnar1+/− males were infected intravaginally with 1.5 × 105 PFU Cambodian ZIKV at E5.5 and harvested at E10.5. RNA was extracted from fetuses, and expression of previously reported hypoxia-response genes Vegfa (A), Adm (B), Bnip3 (C), Pfkfb3 (D), and Glut1 (E) analyzed by reverse transcription qPCR. Data represent n = 9 fetuses per genotype from three litters from ZIKV-infected litters and n = 3 Ifnar1−/− and n = 5 Ifnar1+/− fetuses from two uninfected litters. Data are pooled from at least two independent experiments per group. *P < 0.05, **P < 0.01, and ***P < 0.0001 by Tukey’s multiple comparison test. Data were normalized to Hprt and represented as fold change over Ifnar−/− uninfected placentas. Laura J. Yockey et al. Sci. Immunol. 2018;3:eaao1680 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works