Schematic view of intracellular signaling cascades triggered by receptor tyrosine kinase in Schwann cells. Schematic view of intracellular signaling cascades.

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Schematic view of intracellular signaling cascades triggered by receptor tyrosine kinase in Schwann cells. Schematic view of intracellular signaling cascades triggered by receptor tyrosine kinase in Schwann cells. We propose that upregulation of MAG mRNA implies a transition from immature Schwann cell to the promyelinating state and that myelination will subsequently occur. Activation of both cAMP and Akt-GSK-3β signals and, at the same time, downregulation of MAPK are all required for MAG expression. At present, the targets of these three pathways are not known. Toru Ogata et al. J. Neurosci. 2004;24:6724-6732 ©2004 by Society for Neuroscience