M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia The opening of KATP channels and intact activity of M‐LDH.

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M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia The opening of KATP channels and intact activity of M‐LDH is required for Kir6.2/SUR2A/M‐LDH‐mediated resistance. Original frames and whole‐cell recordings under control and ischemic conditions with corresponding bar (intracellular Ca2+ levels, frames) and scatter‐line graphs (whole‐cell recordings) of A549 cells transfected with Kir6.2/SUR2A/M‐LDH in the presence of 10 μM glybenclamide (A) and transfected with Kir6.2/SUR2A plus 193gly‐M‐LDH (B) (single‐amino acid mutated form of M‐LDH with greatly reduced LDH activity; glybenclamide was absent). Scale bar, 20 μm. Vertical bars represent mean ± SEM; points represent mean (n = 5–9). *P <0.05. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON PERMISSIONS@WILEY.COM OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO J, Volume: 21, Issue: 15, Pages: 3936-3948, First published: 01 August 2002, DOI: (10.1093/emboj/cdf388)