CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

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CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. (A) Schematic depicts the isolation and transfer of SMARTA memory cells (day 42) derived from either day 5 CD25hi or CD25lo effector populations into naïve B6 hosts, followed by secondary challenge with LCMV. (B) Bar graph indicates the fold expansion of each SMARTA population, as measured by splenic cell numbers at day 5 postsecondary challenge. (C) Representative flow plots show the expression of PD-1 and CXCR5 on SMARTA T cells 5 days after LCMV infection. (D) Bar graphs indicate the expression levels of CXCR5, PD-1, Ly6C, Bcl-6, and T-bet in either frequency or MFI via flow cytometry. (E) Bar graphs show the frequency of single and multicytokine-producing SMARTA T cells (day 5 post-infection) after ex vivo peptide restimulation. Error bars indicate SEM, and statistical significance was determined by Student’s t test (n = 3 mice per group). Jeremy P. Snook et al. Sci. Immunol. 2018;3:eaas9103 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works