Week 2: Cable properties (passive membrane properties and disease)

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Presentation transcript:

Week 2: Cable properties (passive membrane properties and disease) BIOL3833 Week 2: Cable properties (passive membrane properties and disease)

Agenda Announcements Brief lecture: “Passive properties and disease states” (15 min) Work on simulation exercises (~60 min).

A quick review

Start with passive properties of a spherical cell – the simplest case we have.

3D Purkinje cell reconstruction

Vrest = -60mV Depolarize to -50 mV

Rm Cm Ra I

Rm Ra How would you increase conduction velocity/efficiency by changing Ra? - What are the limits on this strategy?

Rm Ra How would you increase conduction velocity by changing Rm?

Rm Cm Ra I

On to simulation assignment Today is competence based – when you have finished the simulations you are free to go. Next week: Ion gradients! Why? Because V = IR

Concept Map Resistance Capacitance Cell Membrane Ion channels Time constant Current Conductance Voltage Temporal Fidelity Temporal Summation