A Role for Science Investments in Advancing Newborn Health

Slides:

Advertisements

Similar presentations

Addressing the Challenge of Neonatal Mortality

Advertisements

Bellringer #2: Geography Terms. Birth Rate The # of live births per 1000 individuals within a population. The # of live births per 1000 individuals within.

Overview of the Presentation The presentation aims to answer 4 basic questions 1.What 1.What is the Every Newborn action plan? 2.Why 2.Why the need for.

The Bayh-Dole Act Turns 30 by Vicki Loise, and Ashley J. Stevens Sci Transl Med Volume 2(52):52cm27-52cm27 October 6, 2010 Published by AAAS.

Improving maternal and newborn health in tribal communities in Jharkhand and Orissa, India An evaluation of the impact of participatory community groups.

I may not be Southern by birth, but I am proud to be an American: The role of international medical graduates in vascular surgery and the Southern Association.

The 13th International Conference of the Jordanian Society of Obstetricians and Gynaecologists – 31 August-2 September 2016 Midwives save lives, enhance.

*((Infant Mortality))*

Promosi Kesehatan 7 Oktober 2016

Fig 3. Time trends for infant mortality rate and hazard ratio according to the deprivation quintiles. (A) Time trend for the infant mortality rate according.

Volume 60, Issue 1, Pages (July 2011)

Advances in pediatric asthma in 2011: Moving forward

The Vision The UK and partner countries, through the Newton Fund, will continue to build on existing science and innovation partnerships to promote the.

Respiratory Care of the Newborn: What Does the Future Hold?

Advancing asthma care: The glass is only half full!

Fig. 1. Map showing the study catchment area in the East of England.

Fig. 6 Transmissibility of adiposity from humanized mice to germ-free recipients. Transmissibility of adiposity from humanized mice to germ-free recipients.

Fig. 7 Correlation of NHP and human ISGs.

Fig. 1 Movement percepts for all participants.

Consolidated Standards of Reporting Trials flow diagram of VRC trial

Fig. 2 Whisker deprivation accelerates and enhances behavioral recovery after right S1FP photothrombosis. Whisker deprivation accelerates and enhances.

Fig. 2. Clinically actionable somatic genomic alterations in various tumor types. Clinically actionable somatic genomic alterations in various tumor types.

Fig. 1. Schematic showing the shedding of tumor DNA from head and neck cancers into the saliva or plasma. Schematic showing the shedding of tumor DNA from.

Fig. 3. Comparison of prediction performance.

Fig. 1. Animal instincts. Animal instincts. Half-horse, half-human, the mythological centaur Chiron (root, chirourgos: surgeon) taught all of the great.

Fig. 6. TIV-09, but not MIV-09, induces an IFN signature in the blood of vaccinated individuals at day 1. TIV-09, but not MIV-09, induces an IFN signature.

Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.

Fig. 2. Bacterial/viral score in COCONUT-conormalized whole-blood validation data sets. Bacterial/viral score in COCONUT-conormalized whole-blood validation.

Fig. 5. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota. Vitamin B12 supplementation in the host altered.

Saving Mothers, Giving Life Theory of Change Model Abbreviations: EmONC, emergency obstetric and newborn care; MCH, maternal and child health; MPDSR, maternal.

Fig. 1 Inbred mouse strains carrying monoclonal tumors display a symmetrical yet disparate response to ICB, associated with a distinctive gene signature.

Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.

BMS blocks functional responses in primary immune cells driven by IFNα

Fig. 1. Detection of circulating tumor DNA in CRPC patients.

Fig. 3 Identification of KEECs that increase KCC2 expression in human RTT neurons. Identification of KEECs that increase KCC2 expression in human RTT neurons.

The microchip-based drug delivery device and overview of study design

Fig. 5. Octet BLI competition assay using D25 and motavizumab.

Opening Up to Precompetitive Collaboration

Fig. 2 PK dosing results. PK dosing results. (A) Plasma concentration of hPTH(1–34) versus time after release of 40-μg dose from implanted microchip device.

Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.

Transforming medicine with the microbiome

Single-cell analyses to tailor treatments

PD and efficacy of AZD4785 in KRAS mutant lung cancer xenograft models

Fig. 1 Crohn’s disease association within the LRRK2 locus.

Fig. 2 Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes in cognition. Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes.

A “datathon” model to support cross-disciplinary collaboration

Fig. 8. Purkinje cell quantification and hearing threshold in NPC cats administered IC HPβCD. Purkinje cell quantification and hearing threshold in NPC.

by Peter Bacchetti, Steven G. Deeks, and Joseph M. McCune

Fig. 2 Neonatal ZIKV infection induces seizures in young mice and increases susceptibility to chemically induced seizures in adult mice. Neonatal ZIKV.

Fig. 3 We posit the hyperconcentrated period of domain news, characterized by high article volume and similarity, which G-causes public attention changes.

Delineating cancer evolution with single-cell sequencing

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

Fig. 1. Dysbiosis of the skin microbiome in AD is associated with S

Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.

Making Prospective Registration of Observational Research a Reality

Experimenter gender and replicability in science

Conceptual model of factors that affect treatment effectiveness

Fig. 3. miR overexpression leads to increased cell proliferation as well as altered differentiation and metabolism in cardiomyocytes. miR

Fig. 1. Forecasting the future.

Fig. 1 Closed-loop artificial pancreas systems.

Fig. 1 Advancing ASO therapy for neurological disorders.

Fig. 3. Association between peak CTL019 expansion and response.

Fig. 1. Schematic description of whole-exome or targeted next-generation sequencing analyses. Schematic description of whole-exome or targeted next-generation.

Fig. 8 Immune correlates of protection.

PD and efficacy of AZD4785 in a KRAS wild-type lung cancer PDX model

Fig. 3 Postnatal assembly of the humanized gut microbiota.

Fig. 6. Connectivity and mobility maps for Lesotho.

Fig. 1. Maps of Lesotho, a landlocked country within South Africa.

Presentation transcript:

A Role for Science Investments in Advancing Newborn Health by Zulfiqar A. Bhutta, and Gary L. Darmstadt Sci Transl Med Volume 6(253):253cm8-253cm8 September 10, 2014 Copyright © 2014, American Association for the Advancement of Science

Fig. 1 Conceptual framework. Conceptual framework.The scientific research and development process to define and test intervention efficacy and effectiveness, and to package interventions for delivery, must link with broader processes (policy process), systems (communities and health systems), and factors (social determinants) that influence the intervention’s potential to save lives, promote health, and enhance societies. Zulfiqar A. Bhutta and Gary L. Darmstadt Sci Transl Med 2014;6:253cm8 Copyright © 2014, American Association for the Advancement of Science

Fig. 2 Research funding. Research funding.Donor funding through open, competitive RFPs for newborn health research, shown by (A) newborn condition or (B) research domain, and by countries where the research took place (color-coded by neonatal mortality rate). NMR: neonatal mortality rate (deaths per 1000 live births.)‏ Zulfiqar A. Bhutta and Gary L. Darmstadt Sci Transl Med 2014;6:253cm8 Copyright © 2014, American Association for the Advancement of Science