Patrizia Carrarelli, M. Sc. , Ana Luiza Lunardi Rocha, M. D

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Increased expression of antimüllerian hormone and its receptor in endometriosis Patrizia Carrarelli, M.Sc., Ana Luiza Lunardi Rocha, M.D., Giuseppe Belmonte, M.Sc., Errico Zupi, M.D., Mauricio Simoẽs Abrão, M.D., Felice Arcuri, Ph.D., Paola Piomboni, Ph.D., Felice Petraglia, M.D. Fertility and Sterility Volume 101, Issue 5, Pages 1353-1358 (May 2014) DOI: 10.1016/j.fertnstert.2014.01.052 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Antimüllerian hormone (AMH) and (B) AMH receptor type II (AMHRII) mRNA expression in human eutopic endometrium of healthy women (CTR) and of women with endometriosis (ENDO). On the right side of the graphs are the mRNA expression levels during proliferative (Prol) and secretory (Secr) phases of menstrual cycle. Fold change (y axis) represents mRNA expression normalized to transferrin receptor (TFRC). **P<.01; ***P<.001. Fertility and Sterility 2014 101, 1353-1358DOI: (10.1016/j.fertnstert.2014.01.052) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) AMH and (B) AMHRII mRNA expression in eutopic endometrium of women with endometriosis (ENDO), in ectopic endometrium of women with ovarian endometriosis, and in ectopic endometrium of women with deep endometriosis. Fold change (y axis) represents mRNA expression normalized to TFRC. ***P<.001. Abbreviations as in Figure 1. Fertility and Sterility 2014 101, 1353-1358DOI: (10.1016/j.fertnstert.2014.01.052) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Immunohistochemical analysis of AMH and AMHRII expression in endometriosis. Immunohistochemistry was performed with the use of an indirect peroxidase technique (see Methods). AMH expression in (A) control endometrium, (C) ovarian endometriosis, (E) and deep endometriosis; expression of AMHRII in (B) control endometrium, (D) ovarian endometriosis, and (F) deep endometriosis. Original magnification 100×. Positivity is shown by brown staining. Arrows indicate epithelial cells; asterisks indicate stroma cells. Abbreviations as in Figure 1. Fertility and Sterility 2014 101, 1353-1358DOI: (10.1016/j.fertnstert.2014.01.052) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions