A. D. Leonard, J. P. Thompson, E. L. Hutchinson, S. P. Young, J

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Presentation transcript:

Urotensin II receptor expression in human right atrium and aorta: effects of ischaemic heart disease A.D. Leonard, J.P. Thompson, E.L. Hutchinson, S.P. Young, J. McDonald, J. Swanevelder, D.G. Lambert British Journal of Anaesthesia Volume 102, Issue 4, Pages 477-484 (April 2009) DOI: 10.1093/bja/aep011 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 UT expression measured by quantitative real-time PCR as a function of good (>50%) and impaired (≤50%) LV function in atrium (a) and thoracic aorta (b). There were no differences between the two groups. Data are presented as median, 25th and 75th centiles, and range for (n) samples. In (c), the entire data set for both tissues is compared. ΔCt values in thoracic aorta were significantly higher than in the atrium indicating lower expression. In 25 cases, there were paired samples; when these were analysed using a Wilcoxon signed rank test, the significant difference remained (P=0.033). British Journal of Anaesthesia 2009 102, 477-484DOI: (10.1093/bja/aep011) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 UT expression is not affected by preoperative assessment of cardiac dysfunction using NYHA classification of heart failure or the CCS classification system. Atrial and aortic data are presented in (a) and (b), and (c) and (d), respectively. Data are presented as median, 25th and 75th centiles, and range for (n) samples. NYHA grade 1, no limitation of physical activity; grade 2, mild limitation of physical activity; grade 3, marked limitation of physical activity but comfortable at rest; and grade 4, unable to perform any physical activity without discomfort, symptoms at rest also. CCS class 0, asymptomatic; class 1, angina with strenuous exercise; class 2, angina with moderate exertion; class 3, angina with mild exertion; and class 4, angina with any level of physical exertion. There were no differences between the groups except in the atria where CCS classification system data (b) was significant by Kruskal–Wallis with a post hoc difference between class 2 and class 3 (Dunn's test). British Journal of Anaesthesia 2009 102, 477-484DOI: (10.1093/bja/aep011) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 There was a significant weak negative correlation between atrial UT gene expression (ΔCt) and ejection fraction as measured in the mid-oesophageal two-chamber view. British Journal of Anaesthesia 2009 102, 477-484DOI: (10.1093/bja/aep011) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 4 Plasma UII concentrations (pg ml−1) plotted against preoperative variables; (a) LV function: good (>50%) and impaired (≤50%), (b) NYHA classification of heart failure, or (c) the CCS scale. Data are presented as median, 25th and 75th centiles, and range for (n) samples. NYHA and CCS grade details are as in Figure 2. There was no difference between good and impaired LV function groups. Using Kruskal–Wallis test, there was no difference in the subgrouped UII data. In (a), historical control data from Gold and colleagues15 are included for comparison. British Journal of Anaesthesia 2009 102, 477-484DOI: (10.1093/bja/aep011) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions