Figure 2 Interleukin-6 concentrations in the CSF In 2 mutation carriers (patient 1 in dark blue triangle and patient 5 in light blue triangle carrying.

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Figure 2 Interleukin-6 concentrations in the CSF In 2 mutation carriers (patient 1 in dark blue triangle and patient 5 in light blue triangle carrying the Q703K variant in heterozygous [+/−] and homozygous [+/+] form), interleukin (IL)-6 levels in the CSF were elevated during an acute exacerbation of cryopyrin-associated periodic syndromes (CAPS)-related CNS symptoms, whereas other mutation carriers (represented by black triangles) lacked increased IL-6 levels in CSF during acute CAPS exacerbation compared to controls without mutations in the NLRP3 gene (black squares; n = 3). p Value did not differ significantly (ns = not significant) as assessed by Mann-Whitney U test. Interleukin-6 concentrations in the CSF In 2 mutation carriers (patient 1 in dark blue triangle and patient 5 in light blue triangle carrying the Q703K variant in heterozygous [+/−] and homozygous [+/+] form), interleukin (IL)-6 levels in the CSF were elevated during an acute exacerbation of cryopyrin-associated periodic syndromes (CAPS)-related CNS symptoms, whereas other mutation carriers (represented by black triangles) lacked increased IL-6 levels in CSF during acute CAPS exacerbation compared to controls without mutations in the NLRP3 gene (black squares; n = 3). p Value did not differ significantly (ns = not significant) as assessed by Mann-Whitney U test. Elisabeth Schuh et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e109 © 2015 American Academy of Neurology