Direct recognition of MHC II/TARP14-27 on tumor cells by HTL

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Direct recognition of MHC II/TARP14-27 on tumor cells by HTL Direct recognition of MHC II/TARP14-27 on tumor cells by HTL. A, cell surface expression of HLA-DR molecules on tumor cells. Direct recognition of MHC II/TARP14-27 on tumor cells by HTL. A, cell surface expression of HLA-DR molecules on tumor cells. Tumor cell lines (SKBr3, PC3, and MCF7) were cultured with IFN-γ (500 units/mL) for 48 hours to enhance MHC antigen expression. The expression of HLA-DR molecules on tumor cells was evaluated by staining with anti–HLA-DR (L243) mAb conjugated with fluorescein isothiocyanate (grey line, open histograms). Staining with the isotype negative control (black-filled histograms). B, HLA-DR13–restricted HTL clone produced IFN-γ as the result of recognizing antigen on HLA-DR13+ TARP+ SKBr3 tumor cells presenting naturally processed epitope. C, similarly, the HLA-DR15–restricted HTL clone also produced IFN, as the result of recognizing antigen on HLA-DR15+ TARP+ MCF7 tumor cells. In both cases, production of IFN-γ by the HTL clones was inhibited by anti–HLA-DR mAb L243 at 10 μg/mL. Columns, triplicate determinations; bars, SD. Columns without bars had SD < 10% the value of the mean. Representative of at least two to three experiments that were done with the same samples. Hiroya Kobayashi et al. Clin Cancer Res 2005;11:3869-3878 ©2005 by American Association for Cancer Research