Fig. 2 The sex-linked mbt proteome.

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Fig. 2 The sex-linked mbt proteome. The sex-linked mbt proteome. (A) Venn diagrams showing the number of proteins that present sex-biased expression in mbt (red and blue) and wild-type (brown) larval brains. Top and bottom diagrams show the number of proteins up-regulated in males compared to females and in females compared to males, respectively. (B and C) Plots showing the expression level of the proteins in l(3)mbtts1/Df (B) and control w1118 (C) brains lobes in male (x axis) and female (y axis) samples. Blue and red dots correspond to proteins that are significantly overexpressed in males (M-pSDS) and females (F-pSDS), respectively, in l(3)mbtts1/Df samples. As an example, the points corresponding to Phf7, TrxT, HP1D3csd, CG15930, and CG2812 are identified in the plot (red). Gray dots correspond to proteins that are expressed at levels that are not significantly different between male and female l(3)mbtts1/Df samples. Black dots correspond to the sex determination protein Sxl and to the dosage compensation proteins Msl-1, Msl-3, and Mof. The sex-biased expression of these proteins is unaffected in mbt tumors. Cristina Molnar et al. Sci Adv 2019;5:eaaw7965 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).