Correlation of miR-21 expression levels with DEGs in 28 bladder cancer cell lines. Correlation of miR-21 expression levels with DEGs in 28 bladder cancer.

Slides:

Advertisements

Similar presentations

Hierarchical clustering of DEGs in Shp−/− mice, chronic hepatitis C cirrhosis, and NASH. A: unsupervised hierarchical clustering of genes common to the.

Advertisements

SI-II A SI-II. Expression analysis of bladder cancer functionally active genes and significantly mutated genes. Comprehensive transcriptome profiling of.

Additional file 8: Estimation of biological variations

CYB561 mutations. CYB561 mutations. The upper part shows the structure of the CYB561 gene, with the positions of the identified mutations indicated. Gray.

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Correlation of log-transformed signal intensity from two Affymetrix microarray hybridizations using platelet RNA. Plotted are those probesets with an average.

Differential expression of select miRNAs was validated in a second cohort of patients. Differential expression of select miRNAs was validated in a second.

Characterization of microRNA transcriptome in tumor, adjacent, and normal tissues of lung squamous cell carcinoma Jun Wang, MD, PhD, Zhi Li, MD, PhD,

Comparative analysis of RNA and protein profiles.

a b c Fold Change DeltaCt Cell Line ADAR1 ADAR2 Ratio H ,776

Integrated analysis of miRNA and mRNA during differentiation of human CD34+ cells delineates the regulatory roles of microRNA in hematopoiesis Nalini.

Volume 126, Issue 6, Pages (September 2006)

Volume 85, Issue 2, Pages (January 2014)

Reversing the TERT promoter mutation to WT reverses the active chromatin marks and alters long-range chromatin interactions. Reversing the TERT promoter.

miR-335 targeted RANKL and reduced osteoclast induction in SBC-5.

Diverse abnormalities manifest in RNA

Epigenetic regulation of miR-193b in liposarcomagenesis.

Volume 48, Issue 5, Pages (December 2012)

Properties of proteins and residues with frequent hotspot mutations

Novel p53 target genes identified by RNA-Seq, pSILAC and ChIP-Seq.

FIP200 controls Bak expression via maintaining microRNA1198-5p expression. FIP200 controls Bak expression via maintaining microRNA1198-5p expression. (A)

High correlation of expression changes of NMD-regulated genes identified by both the pSILAC screen and previously reported global RNA screens after UPF1.

Protein microarrays for validation of antibodies.

Functional enrichment of differentially expressed genes.

K-Means clustering of protein and mRNA expression patterns after PPAR agonists treatments. k-Means clustering of protein and mRNA expression patterns after.

Bar plot representation of the transcriptomic changes in Δsaci_ptp and Δsaci_pp2a. Bar plot representation of the transcriptomic changes in Δsaci_ptp and.

Validation of ChIP-seq reads.

Prediction of Plant MicroRNA Targets

Changes in mRNA levels do not correlate with changes in protein levels in upf1Δ and xrn1Δ cells. Changes in mRNA levels do not correlate with changes in.

Limited transcriptomic changes upon HOTAIR RNA overexpression in MDA‐MB‐231 breast cancer cells Limited transcriptomic changes upon HOTAIR RNA overexpression.

Features of the LIMT gene and RNA abundance in cell lines of different tissues of origin Features of the LIMT gene and RNA abundance in cell lines of different.

Differential protein, mRNA, lncRNA and miRNA regulation by p53.

Quantification of MHC-I, β2m, and T-cell subsets.

Molecular Therapy - Nucleic Acids

RNA expression data. RNA expression data. Heat maps comparing the normalized log2 of the ratios of Fur−, F90, and F1 signals on the cl20 control signal.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

USP2a regulates MYC expression through the MDM2–p53 axis.

CaQTL analysis identifies genetic variants affecting human islet cis-RE use. caQTL analysis identifies genetic variants affecting human islet cis-RE use.

MiR-431-5p directly targets RAF1 and is negatively correlated to RAF1 expression (A) The predicted binding sites of miR-431-5p and RAF1 3′-UTR, and mutant.

miR-9 regulation of Pax6 expression.

Cytotoxic activity of HER2-lytic hybrid peptide.

VP16-E2 is a more potent transcriptional activator than Gal4-VP16.

Analysis of PHO1 Expression by RT-qPCR in the pru1 Mutant, Complementation Lines (COM5 and COM7), and Wild-type Plants during Pi Starvation. Analysis of.

CCG regulates cellular localization and blocks target gene expression of MRTF. A, SK-Mel-147 cells were cotransfected with RhoC and the SRE.L reporter.

Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.

Pancreatic cancer cell lines are sensitive to knockdown of outlier kinases. Pancreatic cancer cell lines are sensitive to knockdown of outlier kinases.

Immunohistochemical detection of nuclear and cytoplasmic YB-1 in osteosarcoma and synovial sarcoma. Immunohistochemical detection of nuclear and cytoplasmic.

SAF-1 expression in clinical breast cancer tissues.

PPP2R2A overexpression rescues the miR-21–induced biological effects in bladder cancer cells. PPP2R2A overexpression rescues the miR-21–induced biological.

Targeting DCLK1 by miRNA-137.

Discovered and replicated positive correlation between miR-193b

Radiation does not alter AKT and MTOR gene expression.

Comparison of the frequency of nucleotide variation in the mtDNA D-loop region between stomach and other tumor cell lines. Comparison of the frequency.

Dysregulated NF-κB activation in Il1r8+/+/lpr and Il1r8−/−/lpr mice.

HPV–human protein network map.

Two-way, unsupervised hierarchical clustering representing the 60 tumor cell lines (vertical axis) and the analyzed total, phospho- and cleaved proteins.

Effect of hydrogen peroxide on survival and transcriptional activation of TFF1 in established cell lines from the following human tumor tissues: breast.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression. SBC-5 miR-335+, but not SBC-5 miR-29a+, exhibited reduced IGF-IR expression.

Cell Sorting of Induced SE-like Cells Using SEOR1pro:SEOR1-YFP.

Activity of a chemically modified miR-21 inhibitor in human bladder cancer xenografts. Activity of a chemically modified miR-21 inhibitor in human bladder.

Pancreatic adenocarcinoma, chronic pancreatitis, and normal pancreas samples can be distinguished on the basis of gene expression profiling. Pancreatic.

One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. One-way hierarchical cluster analysis.

Inhibition of CD20 mRNA expression by ibrutinib correlates with reduced NF-κB activity. Inhibition of CD20 mRNA expression by ibrutinib correlates with.

Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. A,

Gene expression heatmap of non–T-cell-inflamed, intermediate, and T-cell–inflamed testicular germ cell tumors from TCGA. Genes are on the row, and samples.

Transcriptomic Analysis of GmSIN1 OE-1 Transgenic Soybean.

Driver pathways and key genes in OSCC

Integrated analysis of gene expression and copy number alterations.

Mutant TERT promoter displays active histone marks and distinct long-range interactions: A, cell lines that were used in the study with their origin and.

Presentation transcript:

Correlation of miR-21 expression levels with DEGs in 28 bladder cancer cell lines. Correlation of miR-21 expression levels with DEGs in 28 bladder cancer cell lines. A, MiR-21 expression levels in 28 bladder cancer cell lines, as assessed by RT-qPCR. qPCR levels (high, medium, low) of miR-21 are annotated along with cell line name. B, 28 bladder cancer cell lines were arrayed against their pooled reference mix, and the name of each cell line is listed on the Y axis. The 15 DEGs are listed on the X axis and attached in hierarchical tree to indicate the distance of relation between each gene. The logarithmic color scheme depicts the expression levels of DEGs expression from higher to lower in red > black > green order. C,In silico complementarity analysis between miR-21 sequence and the coding and 3′UTR sequences for all the 15 genes found to be inversely correlated with miR-21 expression was performed, using the RNA22 v2 microRNA target detection. Criteria that were applied include a size seed of 7 and 11 as the minimum number of paired up bases in heteroduplex and maximum folding energy in heteroduplex, respectively. H, High; M, Medium; L, Low. Data are shown as the mean ± SE. Marina Koutsioumpa et al. Mol Cancer Ther 2018;17:1430-1440 ©2018 by American Association for Cancer Research