A2/Melan-A multimer+ CD8+ allorestricted CTL clones derived from donor DR fail to significantly recognize DR self-targets. A2/Melan-A multimer+ CD8+ allorestricted.

Slides:

Advertisements

Similar presentations

HOST DEFENCE AGAINST TUMORS:

Advertisements

D. Negative fraction after isolation of

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells Andrew Gibson, MRes, Lee Faulkner, PhD, Sally.

Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes by Diana Y. Chen, Arumugam Balamurugan,

Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells by Susanne M. Schmidt,

The T Cell Surface—How Well Do We Know It?

Volume 19, Issue 12, Pages (December 2011)

Expansion and isolation of NY-ESO-1–specific T cell clones.

Epstein-Barr virus–specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy by Claudia Rossig,

ALK as a novel lymphoma-associated tumor antigen: identification of 2 HLA-A2.1–restricted CD8+ T-cell epitopes by Lorena Passoni, Antonio Scardino, Carla.

Promiscuity of the AlloHLA-A2 Restricted T Cell Repertoire Hampers the Generation of Minor Histocompatibility Antigen-specific Cytotoxic T Cells across.

Simultaneous Ex Vivo Expansion of Cytomegalovirus and Epstein-Barr Virus–Specific Cytotoxic T Lymphocytes Using B-Lymphoblastoid Cell Lines Expressing.

CD8+ cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA class Ia/Ib–associated renal carcinoma antigens with ubiquitous or restricted.

Antigen Presenting Phenotype of Hodgkin Reed-Sternberg Cells: Analysis of the HLA Class I Processing Pathway and the Effects of Interleukin-10 on Epstein-Barr.

Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA by Caterina Milazzo, Volker L. Reichardt, Martin.

Mature dendritic cells pulsed with freeze–thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte.

Volume 7, Issue 6, Pages (December 1997)

Figure 3 Immunohistochemical analyses of positive and negative Epstein-Barr virus (EBV) control tissues using immunostaining Immunohistochemical analyses.

Longitudinal dynamics of antigen-specific CD8+cytotoxic T lymphocytes following primary Epstein-Barr virus infection by Mandvi Bharadwaj, Scott R. Burrows,

Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell–depleted stem cell transplantation.

Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo by Suzanne M. McGoldrick, Marie E. Bleakley,

Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses by Cagan Gurer, Till.

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

Volume 8, Issue 5, Pages (May 1998)

Donor T Cells Administered Over HLA Class II Barriers Mediate Antitumor Immunity without Broad Off-Target Toxicity in a NOD/Scid Mouse Model of Acute.

Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemia by Jochen Greiner, Yoko Ono, Susanne.

Volume 6, Issue 2, Pages (February 1997)

Application of the ELISPOT assay to the characterization of CD8+ responses to Epstein-Barr virus antigens by Jie Yang, Victor M. Lemas, Ian W. Flinn, Chris.

SpA-SEA-D227A-induced CTL lyse MAb-coated EC

A comparison of gene transfer and antigen-loaded dendritic cells for the generation of CD4+ and CD8+ cytomegalovirus-specific T cells in HLA-A2+ and HLA-A2−

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells Andrew Gibson, MRes, Lee Faulkner, PhD, Sally.

Andy K. W. Hsu, Beverley M. Kerr, Kathryn L. Jones, Richard B

Volume 18, Issue 9, Pages (September 2010)

MHC-Dependent and -Independent Activation of Human Nickel-Specific CD8+ Cytotoxic T Cells from Allergic Donors1 Corinne Moulon, Doris Wild, Hans Ulrich.

Virus-specific T cell responses are detected in all MERS survivors.

Figure 2 Immunohistological detection of EBV latent and early lytic proteins in MS and control brains Immunohistological detection of EBV latent and early.

Volume 8, Issue 7, Pages (March 1998)

Comparison of ADCC by CD16V-transduced T lymphocytes and autologous NK cell. Comparison of ADCC by CD16V-transduced T lymphocytes and autologous NK cell.

Target cell lysis by ZnT8186–194-reactive CD8+ T cell clones.

Fig. 6. Comparison between the response against transformed tissues and capsule formation.At the cellular level the two responses share many similarities.

The Telomerase Catalytic Subunit Is a Widely Expressed Tumor-Associated Antigen Recognized by Cytotoxic T Lymphocytes Robert H Vonderheide, William C.

Detection of neoantigen-specific T cell recognition in cancer.

Assessing the effect of TNF-α and TRAIL on A2-PPI15–24 CD8 T-cell cytotoxicity. Assessing the effect of TNF-α and TRAIL on A2-PPI15–24 CD8 T-cell cytotoxicity.

Presence of anti-HPV E6/E7 epitope CD8+ T-cell responses in HPV+ OPSCC tumors. Presence of anti-HPV E6/E7 epitope CD8+ T-cell responses in HPV+ OPSCC tumors.

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

Immune/inflammatory infiltrates in colorectal cancer tissue.

Antigen specificity of direct tumor recognition by HTLV-1 Tax–reactive HTLs. The peptide Tax reactive HTLs 5G, 8E, and 9B (A-C) and peptide Tax reactive.

Specific recognition of HOM-MEL-40/SSX2-derived p pulsed targets by p stimulated T-cells from patients with HOM-MEL-40/SSX2 positive breast.

Natural processing and presentation of the HOM-MEL-40/SSX2-derived p peptide. Natural processing and presentation of the HOM-MEL-40/SSX2-derived.

Exosomes inhibit the nuclear translocation of NFAT and NFκB following activation. Exosomes inhibit the nuclear translocation of NFAT and NFκB following.

Specificity of HOM-MEL-40/SSX2 p stimulated CD8+ T-cells.

Volume 26, Issue 6, Pages (June 2018)

Cytotoxicity of p5399–107-induced CTL cells.

NY-ESO-1-specific cytotoxic reactivity of CD4+ T cell clones.

Volume 6, Issue 2, Pages (February 1997)

Specific inhibition of the Fab-HLA-A2/Flu induction of CTL mediated tumor cell lysis by a competing antibody. Specific inhibition of the Fab-HLA-A2/Flu.

HLA-DR53–restricted HTL responses to peptide TARP1-14.

Functional characterization of polyclonal Melan-A monospecific allorestricted CTLs. (A) Recognition of Melan-A peptides by the polyclonal Melan-A monospecific.

Immune responses to 12MP and 6MHP.

The differential susceptibility to CTL-induced lysis does not involve Melan-A antigen expression. The differential susceptibility to CTL-induced lysis.

HLA-A*0201 restriction of SSX2-derived p stimulated CD8+ T-cells.

Cytotoxic activity of CD8+ T-cells stimulated with SSX2-derived p

Pretreatment of donor T cells with a c-Rel antagonist does not impair GVT activity. Pretreatment of donor T cells with a c-Rel antagonist does not impair.

Characterizing an A*1101-restricted SSC-specific CD8+ cytotoxic T-cell clone. Characterizing an A*1101-restricted SSC-specific CD8+ cytotoxic T-cell clone.

Vaccination schedule. Vaccination schedule. Vaccinations were given in cycles; each cycle consisted of four injections (vertical lines). Up to four additional.

Investigation of reactivity of D14 HLA-A

Induction of NY-ESO-1-specific CD4+ and CD8+ T cell responses after in vitro presensitization with NY-ESO-1 p or Ad2/ESO. Induction of NY-ESO-1-specific.

HLA restriction of spCD4 T-cell responses.

Location and modification of potential target peptides within PASD1.

Human monoclonal anti-NY-ESO-1 antibody (12D7) facilitates cross-presentation of a NY-ESO-1-derived, HLA-A2-restriced epitope (NY-ESO-1157–165). Human.

Presentation transcript:

A2/Melan-A multimer+ CD8+ allorestricted CTL clones derived from donor DR fail to significantly recognize DR self-targets. A2/Melan-A multimer+ CD8+ allorestricted CTL clones derived from donor DR fail to significantly recognize DR self-targets. (A) The lytic activity of A2/Melan-A multimer+ CD8+ allorestricted CTL clones from DR was assessed on NA8 cells, as well as on DR-derived Epstein-Barr virus (EBV)-transformed cells as a source of autologous target cells. Data are shown for clone DR/A1B4; similar data (lack of reactivity toward DR EBV cells both in the absence or in the presence of peptide Melan-A 26-35 A27L) were obtained in the case of other DR allorestricted clones, as well as for the T cell line Bulk DR. (B) The ability of DR EBV cells to be specifically lysed by an HLA-A1-restricted polyclonal line specific for peptide Flu NP 44-52 in the presence, but not in the absence, of the latter was also assessed as an internal control. Valérie Dutoit et al. Cancer Immun 2002;2:7 Copyright © 2002 by Danila Valmori