Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy S.G. Soriano,

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Presentation transcript:

Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy S.G. Soriano, L.J. Sullivan, K Venkatakrishnan, D.J. Greenblatt, J.A.J. Martyn British Journal of Anaesthesia Volume 86, Issue 2, Pages 223-229 (February 2001) DOI: 10.1093/bja/86.2.223 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Vecuronium (a) and 3-desacetylvecuronium (b) plasma concentrations are plotted against time (semilogarithmic plot) after a single bolus dose of vecuronium 0.15 mg kg−1. Mean (sd) are plotted for each group. The metabolite 3-desacetylvecuronium could be detected within 5 min of the bolus of vecuronium. There were no significant differences between groups. British Journal of Anaesthesia 2001 86, 223-229DOI: (10.1093/bja/86.2.223) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Plasma concentrations of vecuronium are plotted against degree of neuromuscular block. Mean values and the predicted curves are plotted for each group. There were no significant differences between the groups in the hysteresis in the concentration–effect curves. British Journal of Anaesthesia 2001 86, 223-229DOI: (10.1093/bja/86.2.223) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 Per cent recovery T1/T0 is plotted against time after a single dose of vecuronium 0.15 mg kg−1. Data are mean (sd) for all three groups. Recovery times for the phenytoin and carbamazepine groups were significantly different from control. British Journal of Anaesthesia 2001 86, 223-229DOI: (10.1093/bja/86.2.223) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 4 Plot of individual plasma α1-acid glycoprotein concentrations against recovery T1/T0. Pearson product–moment correlation coefficient analysis showed no significant relationship between the two variables. British Journal of Anaesthesia 2001 86, 223-229DOI: (10.1093/bja/86.2.223) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions