The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle distribution. The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle.

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The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle distribution. The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle distribution. A and B, IAA, not glycyrrhizin, suppresses anchorage-dependent growth of SK-MEL-28 cells. SK-MEL-28 cells were treated with IAA (A) or glycyrrhizin (B; 0, 10, or 20 μmol/L) for the indicated times. Proliferation was determined by MTS assay. C and D, IAA, not glycyrrhizin, causes SK-MEL-28 cell-cycle arrest at G1-phase. Cells were treated with IAA (C) or glycyrrhizin (D) at the indicated concentrations for 48 hours. The effects of IAA and glycyrrhizin on cell-cycle distribution are presented as the percentage of IAA- or glycyrrhizin-treated cells at the G1, S, or G2–M phase of cell cycle compared with untreated control cells. Data are shown as mean ± SD of three samples from three independent experiments. The asterisks indicate a significant difference (***, P < 0.001) in the number of cells after treatment with IAA versus untreated control group. Nu Ry Song et al. Cancer Prev Res 2013;6:1293-1303 ©2013 by American Association for Cancer Research