Epigenome Sequencing Comes of Age

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Epigenome Sequencing Comes of Age Jian-Kang Zhu Cell Volume 133, Issue 3, Pages 395-397 (May 2008) DOI: 10.1016/j.cell.2008.04.016 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 DNA Methyltransferases and Demethylases in Arabidopsis DNA methyltransferases can be targeted by both small RNA-dependent and RNA-independent pathways to achieve methylation at CG or non-CG sites. For some loci, DNA demethylases actively remove methylation to prevent silencing. Small RNA production is controlled by DNA methylation in a self-reinforcing positive feedback loop. The dotted line indicates the possibility that small RNAs may direct heterochromatic histone modifications. Cell 2008 133, 395-397DOI: (10.1016/j.cell.2008.04.016) Copyright © 2008 Elsevier Inc. Terms and Conditions