Fig. 5 A holistic formula TNTL targeting SBP2 in ATMs improved insulin resistance in obese mice. A holistic formula TNTL targeting SBP2 in ATMs improved.

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Fig. 5 A holistic formula TNTL targeting SBP2 in ATMs improved insulin resistance in obese mice. A holistic formula TNTL targeting SBP2 in ATMs improved insulin resistance in obese mice. (A) SBP2 expression in M1-like BMDMs was notably higher after oral (per os, p.o.) treatment with TNTL. (B and C) TNTL treatment induced SBP2 expression in ATMs of db/db mice. (D) Macrophage-specific knockdown of SBP2 in TNTL-treated mice abrogated the effects of TNTL. (E) TNTL treatment did not affect body weight gain but (F) reduced adipose tissue weight. Knockdown of SBP2 in ATMs abrogated the therapeutic effect of TNTL on (G) FBG levels, (H) glucose intolerance, (I) insulin sensitivity, (J) serum HbA1c levels, and (K) sensitized adipose insulin-responsive Akt pathway. *P < 0.05, **P < 0.01, ***P < 0.001. Ning Wang et al. Sci Adv 2019;5:eaav0198 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).