CD25 expression predicts effector and memory differentiation.

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CD25 expression predicts effector and memory differentiation. CD25 expression predicts effector and memory differentiation. (A) Schematic depicts isolation and transfer of CD25hi and CD25lo early effector SMARTA CD4+ T cells infection-matched secondary hosts. (B) Graph indicates the frequency of SMARTA cells (Thy1.1+) in the blood of secondary hosts at the indicated time points after transfer of CD25hi (“High”) and CD25lo (“Low”) SMARTA cells at day 5 post-infection (p.i.). (C) Bar graph indicates the total number of SMARTA memory cells (day 42 post-infection) in the spleen and liver after transfer of equal numbers of CD25hi or CD25lo early effector cells into infection-matched hosts at either days 3 or 5 post-infection. (D) Plots indicate the frequency of CXCR5hiPD-1hi Tfh effector cells derived from CD25lo and CD25hi effector SMARTA that were transferred at day 5 and analyzed at day 8. (E) Bar graphs depict the frequency of Tfh (CXCR5hiPD-1hi) and TH1 (Ly6Chi) day 8 effector cells derived from CD25hi and CD25lo early effector cells isolated and transferred at day 5 post-infection. Remaining bar graphs depict the MFI of Bcl-6 and T-bet at day 8. (F) Bar graphs show the frequency of CXCR5+ SMARTA cells in the spleen and the MFI after intracellular antibody staining for the presence of Bcl-6 and T-bet. Error bars indicate SEM, and statistical significance was determined by Student’s t test (n = 3 to 5 mice per group, representative of at least three independent experiments). *P < 0.05, **P < 0.01, ***P < 0.001. Jeremy P. Snook et al. Sci. Immunol. 2018;3:eaas9103 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works