Volume 24, Issue 1, Pages 7-8 (July 2016)

Slides:

Advertisements

Similar presentations

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Advertisements

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase Simon A. Hawley, David A. Pan, Kirsty J.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Volume 14, Issue 2, Pages (August 2011)

Does Reduced Creatine Synthesis Protect against Statin Myopathy?

Making Muscle or Mitochondria by Selective Splicing of PGC-1α

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans

Something Old, Something New, Something Borrowed …

All roads lead to FoxO Cell Metabolism

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

Megarole for MicroRNA in Muscle Disease

Pancreatic β cells: Responding to the matrix

Volume 13, Issue 1, Pages 5-6 (January 2011)

Serotonin and the Orchestration of Energy Balance

Volume 23, Issue 3, Pages (March 2016)

Volume 26, Issue 1, Pages (July 2017)

Metabolic Regulation of Stem Cell Behavior and Implications for Aging

Gal3 Links Inflammation and Insulin Resistance

Can Exercise Mimetics Substitute for Exercise?

Volume 15, Issue 1, Pages (January 2012)

Is Predisposition to NAFLD and Obesity Communicable?

Volume 142, Issue 4, Pages (August 2010)

Exercise Has a Bone to Pick with Skeletal Muscle

Volume 13, Issue 1, Pages 5-6 (January 2011)

Megarole for MicroRNA in Muscle Disease

Insulin biosynthesis: The IREny of it all

The CAMplexities of Central Ghrelin

Adiponectin Sparks an Interest in Calcium

Volume 46, Issue 5, Pages (June 2012)

Computing at the Front-End by Receptor Networks

The Importance of Timing

Irisin, Turning Up the Heat

Autophagy: A Potential Link between Obesity and Insulin Resistance

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Metformin and Insulin Meet in a Most Atypical Way

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism David Carling, Benoit Viollet Cell Metabolism

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Silencing Insulin Resistance through SIRT1

Estrogen Receptors and the Metabolic Network

GDF11 and the Mythical Fountain of Youth

Insulin Action under Arrestin

Banking on ATM as a new target in metabolic syndrome

A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life

Autophagy Works Out Cell Metabolism

Proteins in Plant Brassinosteroid Signaling

Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

Exercise Controls Non-Coding RNAs

Volume 14, Issue 2, Pages (August 2011)

Hap1 and GABA: Thinking about food intake

Macrophage Metabolism Shapes Angiogenesis in Tumors

BDNF (I)rising from Exercise

Ye-Guang Chen, Zhongwei Li, Xiao-Fan Wang Cell Stem Cell

Many Roads Lead to the Lipid Droplet

David Hubel and Torsten Wiesel

Rejuvenation: It’s in Our Blood

Marking Emerging β- and γδ-Selected T Cells

Cellular Alchemy and the Golden Age of Reprogramming

The Regulatory T Cell Transcriptosome: E Pluribus Unum

AMPK and p53 help cells through lean times

Estrogens and Obesity: Is It All in Our Heads?

Skp2, the FoxO1 hunter Cancer Cell

Presentation transcript:

Volume 24, Issue 1, Pages 7-8 (July 2016) Elevated GDF11 Is a Risk Factor for Age-Related Frailty and Disease in Humans David J. Glass Cell Metabolism Volume 24, Issue 1, Pages 7-8 (July 2016) DOI: 10.1016/j.cmet.2016.06.017 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 GDF11 Total Protein Levels and Mechanism Myostatin, GDF11, and activin signal through the ActRII/Alk4,5 complex, inducing SMAD2 and SMAD3 phosphorylation. This results in a decrease in skeletal muscle growth. Schafer et al. (2016) find high levels of GDF11 to be associated with frailty and other co-morbidities of the aged. In human beings, GDF11 is not regulated by age, whereas myostatin decreases in males. Cell Metabolism 2016 24, 7-8DOI: (10.1016/j.cmet.2016.06.017) Copyright © 2016 Elsevier Inc. Terms and Conditions