M-Wnt and E-Wnt cells cluster tightly with claudin-low and basal-like breast tumors, respectively, by microarray analysis. M-Wnt and E-Wnt cells cluster.

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1 April, 2005 Chapter C4.1 and C5.1 DNA Microarrays and Cancer.

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سرطان الثدي Breast Cancer

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M-Wnt and E-Wnt cells cluster tightly with claudin-low and basal-like breast tumors, respectively, by microarray analysis. M-Wnt and E-Wnt cells cluster tightly with claudin-low and basal-like breast tumors, respectively, by microarray analysis. A, overview of the complete hierarchical gene cluster diagram using 666 intrinsic genes. B, experimental sample-associated dendrogram showing the sample cluster relationships; M-Wnt and E-Wnt cell lines are indicated in red. M-Wnt cell lines cluster with claudin-low tumors, and E-Wnt cell lines cluster with basal-like tumors from C3-Tag transgenic mice (clustering indicated by boxes). C, expanded view of clustered genes having low expression levels in the claudin-low breast tumor subtype including Claudin 3 and 7. D, expanded view of a cluster of genes having high expression levels in the basal tumor subtype including Keratin 5. E, expanded view of a second set of genes having high expression levels in the basal tumor subtype encoding components of the basal lamina and including Keratins 14 and 17. Sarah M. Dunlap et al. Cancer Prev Res 2012;5:930-942 ©2012 by American Association for Cancer Research