Volume 4, Issue 4, Pages (October 2003)

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Volume 4, Issue 4, Pages 248-249 (October 2003) No PUMA, no death Jian Yu, Lin Zhang Cancer Cell Volume 4, Issue 4, Pages 248-249 (October 2003) DOI: 10.1016/S1535-6108(03)00249-6

Figure 1 PUMA is essential for p53-dependent and -independent apoptosis p53 induces either cell cycle arrest or apoptosis depending on cell type and subcellular context. PUMA is required for p53-dependent apoptosis induced by DNA damage, hypoxia, and oncogenes. PUMA is also necessary for apoptosis induced by p53-independent stimuli including serum withdrawal, glucocorticoids, kinase inhibitors, and phorbol esters. p53-dependent cell cycle arrest is mediated by p21 and 14-3-3σ. Cancer Cell 2003 4, 248-249DOI: (10.1016/S1535-6108(03)00249-6)