How I treat disseminated intravascular coagulation

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How I treat disseminated intravascular coagulation by Marcel Levi, and Marie Scully Blood Volume 131(8):845-854 February 22, 2018 ©2018 by American Society of Hematology

Mononuclear cells express tissue factor resulting in thrombin generation and subsequent fibrinogen to fibrin conversion, which, in combination with increased platelet vessel wall interaction and activation of platelets, contribute to microvascular clot form... Mononuclear cells express tissue factor resulting in thrombin generation and subsequent fibrinogen to fibrin conversion, which, in combination with increased platelet vessel wall interaction and activation of platelets, contribute to microvascular clot formation. P-selectin released from activated platelets further upregulates tissue factor expression. Binding of fibrin to Toll-like receptor 4 and activated coagulation proteases to specific protease activated receptors (PARs) on inflammatory cells (dotted lines) modulates inflammation through the additional release of proinflammatory cytokines. Cytokines also play a key role in the suppression of endogenous fibrinolysis and impairment of physiological anticoagulant pathways, such as the APC pathway. Marcel Levi, and Marie Scully Blood 2018;131:845-854 ©2018 by American Society of Hematology

Flowchart for the diagnostic and therapeutic management of DIC Flowchart for the diagnostic and therapeutic management of DIC. LMW, low molecular weight. Flowchart for the diagnostic and therapeutic management of DIC. LMW, low molecular weight. Marcel Levi, and Marie Scully Blood 2018;131:845-854 ©2018 by American Society of Hematology