Nomenclature of Voltage-Gated Calcium Channels

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Nomenclature of Voltage-Gated Calcium Channels Eric A. Ertel, Kevin P. Campbell, Michael M. Harpold, Franz Hofmann, Yasuo Mori, Edward Perez-Reyes, Arnold Schwartz, Terry P. Snutch, Tsutomu Tanabe, Lutz Birnbaumer, Richard W. Tsien, William A. Catterall Neuron Volume 25, Issue 3, Pages 533-535 (March 2000) DOI: 10.1016/S0896-6273(00)81057-0

Figure 1 Phylogeny of Voltage-Gated Ca2+ Channel α1 Subunits Only the membrane-spanning segments and the pore loops (∼350 amino acids) are compared. First, all sequence pairs were compared, which clearly defines three families with intrafamily sequence identities above 80% (CaV1.m, CaV2.m, CaV3.m). Then, a consensus sequence was defined for each family, and these three sequences were compared to one another, with interfamily sequence identities of ∼52% (CaV1.m versus CaV2.m) and 28% (CaV3.m versus CaV1.m or CaV2.m). Neuron 2000 25, 533-535DOI: (10.1016/S0896-6273(00)81057-0)