Fig. 3 In vivo monitoring of vitamin E distribution on mouse skin.

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Fig. 3 In vivo monitoring of vitamin E distribution on mouse skin. In vivo monitoring of vitamin E distribution on mouse skin. (A) Experiment configuration. The nude mouse was anesthetized with isoflurane. (B)Spontaneous Raman spectra of vitamin E, olive oil (rich in CH2), and bovine serum albumin (rich in CH3). (C) MCR output spectra of three components assigned to lipid, protein, and vitamin E. (D) MCR concentration maps of lipid (in yellow) and protein (in green) before and after the treatment. (E) SRG images at 2911 cm−1. The pixel dwell time was 60 μs. Scale bar, 100 μm. Chien-Sheng Liao et al. Sci Adv 2015;1:e1500738 Copyright © 2015, The Authors