Detection and localization of surgically resectable cancers with a multi-analyte blood test by Joshua D. Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn,

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Presentation transcript:

Detection and localization of surgically resectable cancers with a multi-analyte blood test by Joshua D. Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Ludmila Danilova, Christopher Douville, Ammar A. Javed, Fay Wong, Austin Mattox, Ralph H. Hruban, Christopher L. Wolfgang, Michael G. Goggins, Marco Dal Molin, Tian-Li Wang, Richard Roden, Alison P. Klein, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Natalie Silliman, Maria Popoli, Joshua T. Vogelstein, James D. Browne, Robert E. Schoen, Randall E. Brand, Jeanne Tie, Peter Gibbs, Hui-Li Wong, Aaron S. Mansfield, Jin Jen, Samir M. Hanash, Massimo Falconi, Peter J. Allen, Shibin Zhou, Chetan Bettegowda, Luis A. Diaz, Cristian Tomasetti, Kenneth W. Kinzler, Bert Vogelstein, Anne Marie Lennon, and Nickolas Papadopoulos Science Volume 359(6378):926-930 February 23, 2018 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

Fig. 1 Development of a PCR-based assay to identify tumor-specific mutations in plasma samples. Development of a PCR-based assay to identify tumor-specific mutations in plasma samples. Colored curves indicate the proportion of cancers of the eight types evaluated in this study that can be detected with an increasing number of short (<40 bp) amplicons. The sensitivity of detection increases with the number of amplicons but plateaus at ~60 amplicons. Colored dots indicate the fraction of cancers detected by using the 61-amplicon panel used in 805 cancers evaluated in our study, which averaged 82%. Publicly available sequencing data were obtained from the COSMIC repository. Joshua D. Cohen et al. Science 2018;359:926-930 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

Fig. 2 Performance of CancerSEEK. Performance of CancerSEEK. (A) ROC curve for CancerSEEK. The red point on the curve indicates the test’s average performance (62%) at >99% specificity. Error bars represent 95% confidence intervals for sensitivity and specificity at this particular point. The median performance among the eight cancer types assessed was 70%. (B) Sensitivity of CancerSEEK by stage. Bars represent the median sensitivity of the eight cancer types, and error bars represent standard errors of the median. (C) Sensitivity of CancerSEEK by tumor type. Error bars represent 95% confidence intervals. Joshua D. Cohen et al. Science 2018;359:926-930 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

Fig. 3 Identification of cancer type by supervised machine learning for patients classified as positive by CancerSEEK. Identification of cancer type by supervised machine learning for patients classified as positive by CancerSEEK. Percentages correspond to the proportion of patients correctly classified by one of the two most likely types (sum of light and dark blue bars) or the most likely type (light blue bar). Predictions for all patients for all cancer types are provided in table S8. Error bars represent 95% confidence intervals. Joshua D. Cohen et al. Science 2018;359:926-930 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works