TFII-IΔ and TFII-Iβ: Unequal Brothers Fostering Cellular Proliferation

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TFII-IΔ and TFII-Iβ: Unequal Brothers Fostering Cellular Proliferation Lisa Santolin, Michael Meisterernst Molecular Cell Volume 24, Issue 2, Pages 169-171 (October 2006) DOI: 10.1016/j.molcel.2006.10.003 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Model for TFII-I-Mediated Import of ERK and Control of c-fos Transcription TFII-IΔ initially functions as a shuttle for ERK from the cytoplasm into the nuclear compartment. At the c-fos promoter, TFII-Iβ represses transcription in the basal state (right), whereas TFII-IΔ is thought to support its activation upon growth factor signaling (left). SEF and PEA-15 have been described as factors that sequester ERK in the cytoplasm and control its activity. Molecular Cell 2006 24, 169-171DOI: (10.1016/j.molcel.2006.10.003) Copyright © 2006 Elsevier Inc. Terms and Conditions