Oxidative stress is an imbalance between reactive oxygen species (ROS) and antioxidants. a) Under normal conditions there are sufficient antioxidants in.

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Oxidative stress is an imbalance between reactive oxygen species (ROS) and antioxidants. a) Under normal conditions there are sufficient antioxidants in the lung to overcome endogenous ROS. b) During pathologic states there is an increase in ROS that may be... Oxidative stress is an imbalance between reactive oxygen species (ROS) and antioxidants. a) Under normal conditions there are sufficient antioxidants in the lung to overcome endogenous ROS. b) During pathologic states there is an increase in ROS that may be balanced by increase in antioxidants. c) When either ROS production is excessive or antioxidants are inadequate, the balance is tipped toward oxidative stress and injury from ROS may occur. W. MacNee Eur Respir Rev 2005;14:12-22 ©2005 by European Respiratory Society