Volume 63, Issue 1, Pages (January 2003)

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Volume 63, Issue 1, Pages 291-297 (January 2003) Muscle atrophy in patients receiving hemodialysis: Effects on muscle strength, muscle quality, and physical function Kirsten L. Johansen, Tiffany Shubert, Julie Doyle, Brian Soher, Giorgos K. Sakkas, Jane A. Kent-Braun Kidney International Volume 63, Issue 1, Pages 291-297 (January 2003) DOI: 10.1046/j.1523-1755.2003.00704.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Representative magnetic resonance images of the lower right leg. (A) A 72-year-old female control subject. (B) A 70-year-old female hemodialysis subject. Contractile tissue appears dark, while fat and bone appear white. The region of interest (anterior compartment) is outlined in white. There is more noncontractile tissue in the anterior compartment of the dialysis subject. Kidney International 2003 63, 291-297DOI: (10.1046/j.1523-1755.2003.00704.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Total, contractile (▪), and noncontractile () muscle area. Error bars represent the standard deviations for total cross-sectional area. There is no significant difference in total cross-sectional area (P = 0.93), but dialysis subjects have significantly less contractile tissue and more non-contractile tissue (P = 0.001 for both comparisons). Kidney International 2003 63, 291-297DOI: (10.1046/j.1523-1755.2003.00704.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between contractile cross-sectional area (CSA) and maximum voluntary contraction (MVC). The relationship between contractile CSA and MVC is not significantly different (P = 0.13) in dialysis subjects (▪) and healthy sedentary control subjects (○). For dialysis subjects, r = 0.60, P = 0.003, and for control subjects, r = 0.73, P = 0.001. Kidney International 2003 63, 291-297DOI: (10.1046/j.1523-1755.2003.00704.x) Copyright © 2003 International Society of Nephrology Terms and Conditions