A binding relationship with thrombin

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A binding relationship with thrombin by Jerry Ware Blood Volume 127(5):525-526 February 4, 2016 ©2016 by American Society of Hematology

Signaling-mediated cooperativity between platelet GPIb-IX and PAR1. Signaling-mediated cooperativity between platelet GPIb-IX and PAR1. Depicted is a model for independent thrombin binding to 2 different platelet receptors that elicit mutually dependent signals via the 14-3-3-Rac1-LIMK1 pathway. See Figure 6i in the article by Estevez et al that begins on page 626. Jerry Ware Blood 2016;127:525-526 ©2016 by American Society of Hematology